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Posts tagged with "Clinical Trials"

  • Cardiovascular Disease

    Two Diabetes Drug Mysteries

    Here are some data to file under “Drugs do things that we don’t expect”. The SGLT-2 inhibitors are a class of diabetes medications that work by inhibiting the sodium/glucose transporter 2 protein in the kidneys. That keeps glucose from being reabsorbed there; instead, more of it is removed in the urine, and that lowers circulating… Read More
  • Cancer

    Why Did This IDO Inhibitor Trial Fail?

    Let’s put this one under the “This is why you run clinical trials” heading. A number of companies have looked at inhibitors of indoleamine 2,3 dioxygenase (IDO) over the last few years. The enzyme turns tryptophan into kynurenine, a pathway which (among other things) regulates immune function. Evidence has accumulated that many… Read More
  • Alzheimer's Disease

    A Movement Towards Tau in Alzheimer’s?

    Failure after failure has been the story on amyloid-targeting therapies in Alzheimer’s. Tau protein, which is involved in pathology of its own in the disease, has been less in the spotlight (although TauRx has done its part by missing its clinical endpoints with its own drug). But there’s a lot of activity going on with… Read More
  • Cardiovascular Disease

    Thoughts on An Antibody Failure

    Talking with some drug discovery folks the other day, I said “You know, if you don’t hold your breath when your compound goes into tox testing, you haven’t been doing this stuff long enough”. Well, it’s pretty hard to hold your breath across a full tox study, but you know what I mean. There are… Read More
  • Clinical Trials

    I’m Surprised That They’re Surprised

    This article at the Wall Street Journal should not come as a particular surprise to anyone who followed the Sarepta/eteplirsen story over the last few years. But it’s a good overview of it, and it brings up several questions. (My own take on the drug approval is here – I didn’t think it should have… Read More
  • Cardiovascular Disease

    Now This Is A Drug That Does Not Work

    I’ve already written about how Eli Lilly’s inhibitor of cholesteryl ester transfer protein (CETP) did not work in the clinic. Now that the data from their failed trial have been published in the NEJM, though, it’s worth taking a look at a few graphs (first pointed out to me on Twitter by Sek Kathiresan. Shown are… Read More
  • Biological News

    A Look at Antibody Therapies

    Since we were just talking about antibody therapies in immuno-oncology, here’s a timely column by Bruce Booth at LifeSciVC on antibody therapies in general. It’s well worth a read if, like many small-molecule drug discovery folks, you haven’t had to keep up with that area. I’ve written a few times over the years about how… Read More
  • Biological News

    Turmoil in Immuno-oncology

    Immuno-oncology! It’s such a big deal, let’s just do what everyone in the field is doing and call it “IO”. The recent successes in this area have rearranged every company’s oncology strategy, in some cases rearranging its entire oncology portfolio right out the door. There are several possibilities open to you now, if… Read More
  • Alzheimer's Disease

    There Are Failures, You Know

    This exact point came up around here when we last discussed FDA reform, so it’s good to see it made at length in the New England Journal of Medicine. Remember solanezumab? That was the amyloid-targeting antibody that Eli Lilly kept on investigating in trial after trial, looking for some effect on Alzheimer’s. Last November, the final… Read More
  • Cancer

    Kite’s Latest News

    Readers will surely recall the problems that surfaced last year with Juno’s CAR-T cell therapy program. There were a number of patient deaths, and worried onlookers were wondering how their competitor, Kite Pharma, was doing. Well, now there’s word that a patient in one of their trials has died from what’s described as multiple or… Read More
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