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Posts tagged with "Diabetes and Obesity"

  • Biological News

    Type 2 Diabetes May Be a Protein Misfolding Disease

    Here’s a paper that will not calm anyone down about the possibility of prion-like diseases. Those, as many will know, are spread by misfolded proteins that, on contact, template others to follow their example. I last wrote about this field a couple of years ago, when examples appeared of transmissable amyloid pathology in humans, spread… Read More
  • Cardiovascular Disease

    AMPK: Time To Think Hard

    AMP-activated protein kinase, now that’s an enzyme for you. It sits at the center of a cell’s metabolic switchboard, and if you’re talking about anything to do with the response to levels of fuel like glucose or fatty acids and determination of their downstream fates, then AMPK is almost certainly crucial. Activating the enzyme se… Read More
  • Cardiovascular Disease

    Two Diabetes Drug Mysteries

    Here are some data to file under “Drugs do things that we don’t expect”. The SGLT-2 inhibitors are a class of diabetes medications that work by inhibiting the sodium/glucose transporter 2 protein in the kidneys. That keeps glucose from being reabsorbed there; instead, more of it is removed in the urine, and that lowers circulating… Read More
  • Diabetes and Obesity

    A New Diabetes Approach? Small-Molecule Screening Wins Again

    The molecular biology/chemical biology tools we have now are quite something, and have opened up whole areas of research that previously wouldn’t have been feasible. But as a chemist, I’m glad to say that there’s often still nothing like a small molecule. That’s one of the things I take away from this recent paper in… Read More
  • Business and Markets

    Zafgen’s Second Act

    F. Scott Fitzgerald was a very good writer, but one of his most famous lines is about as wrong as it can be. It’s actually a cliché to point out the complete wrongheadedness of “There are no second acts in American lives”, such are the huge number of counterexamples. And that goes for biopharma, too. I’ve written… Read More
  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More
  • Biological News

    Galvani: GSK Goes “Bioelectronic”

    You’ll likely have seen the news that GSK is partnering with Verily (a Google startup) to launch a company called Galvani. This will investigate devices that directly modify nerve transmission, which is something that I don’t think any large drug company has ever put money into – certainly not the $700 million that GSK has… Read More
  • Cardiovascular Disease

    From the Far Corner of the Basement

    To go along with that recent CETP trial news, here’s another one for the “We don’t know much about human lipid handing” file. A dietary study originally done back in the 1960s and 1970s has been (almost literally) resurrected, with data pulled out of yellowing stacks of paper, old cardboard boxes, and ancient-format computer… Read More
  • Business and Markets

    Inhaled Insulin Strikes (Out) Again

    The Wall Street Journal has a good post-mortem of Sanofi’s inhaled insulin experience with Mannkind. I was puzzled by that deal when it was announced, because I’d had a long history of being puzzled by Mannkind and their product (not to mention by their investors, who are a breed apart). Well, they were, anyway – Read More
  • Diabetes and Obesity

    Three Not-So-Reproducible Papers

    You may well remember Amgen’s statement in 2012 about how many academic papers they were having trouble reproducing. Not everyone has taken it seriously, since they didn’t provide specific details, just an overall count. (On the other hand, a lot of people inside the drug industry just nodded their heads, having had similar – and… Read More
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