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  • Calcium Probe Problems

    Fluorescent dyes and probes are wonderful things, and they have been absolutely crucial to our understanding of cellular biology. Being able to see specific pro… Read More
  • PAINs by X-Ray

    It’s safe to say that the concept of “pan-assay interference compounds” evokes some strong feelings in medicinal chemists. And those feelings… Read More
  • A Hard Look At Liquid Biopsies

    This new paper has generated a lot of headlines (Science news writeup here). It reports work on the long-sought “liquid biopsy” idea for cancer scre… Read More
  • The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Mu… Read More
  • New Antibiotic Action

    I’m always happy to hear about new agents to treat gram-negative bacterial infections, especially after a stint working in antibiotic drug discovery mysel… Read More
  • HAT Inhibitors: Interpret With Care

    There are quite a few histone deacetylase inhibitors out there, from research tools to FDA-approved drugs. Those inhibit the enzymes that remove the acetyl epig… Read More
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