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  • Aggregator Aggravation, In a New Way

    Experienced drug discovery folks, particularly those that work early on in the process, will tell you that aggregation is one of the most common sources of fals… Read More
  • Modifying Natural Products, And How

    The field of late-stage modification of complex structures has seen several advances in the last few years, and this is just the sort of thing that medicinal ch… Read More
  • Past the Limits

    Michael Gilman has an interesting article up at LinkedIn about trying to get past the current small-molecule limits of medicinal chemistry. His suggestion is &# Read More
  • No Easy Road to Getting Rid of PAINS

    Here’s a warning about trying to write compounds off too quickly as PAINs (pan-assay interference compounds). The authors, from UNC-Chapel Hill, have gone… Read More
  • The Weirdness of Ebselen

    I think that most medicinal chemists look at the structure of ebselen and say “That’s not a drug”. Selenium atoms don’t belong in drugs… Read More
  • Curcumin Will Waste Your Time

    I really enjoyed reading this article in J. Med. Chem. on curcumin. (Update: here’s the take over at Practical Fragments). That’s a well-known natur… Read More
  • Right Hand, Left Hand, Either Hand

    Medicinal chemists like it when one enantiomer of a compound binds to a target much more than the other one. That tells you that you’re getting real bindi… Read More
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