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Posts tagged with "Drug Assays"

  • Chemical News

    What’s Translational Synthesis, Anyway?

    There’s another paper in the Nature Chemical Biology special issue that I wanted to mention, this one on “Translational Synthetic Chemistry”. I can’t say that I like the title, which seems to me to have a problem with reification (the process of trying to make something a thing which isn’t necessarily a thing at all). Read More
  • Drug Assays

    Fragments For Receptors: It Can Be Done

    The advent of real X-ray structures for receptors means that there are many experimental approaches that can now be tried that earlier would have been (most likely) foolhardy. My first research in the industry was on dopamine receptors, which I followed up by a stint on muscarinics, and we really did try to be rational… Read More
  • Drug Assays

    Pharmacology Versus Biology

    There’s a comment made by CellBio to the recent post on phenotypic screening that I wanted to highlight I think it’s an important point: In drug discovery, we need fewer biologists dedicated to their biology, and more pharmacologists dedicated to testing the value of compounds. He’s not the first one to bemoan the decline of… Read More
  • Analytical Chemistry

    Mass Spec Continues Its Conquests

    You know, mass spectrometry has been gradually taking over the world. Well, maybe not your world, but mine (and that of a lot of biopharma/biophysical researchers). There are just so many things that you can do with modern instrumentation that the assays and techniques just keep on coming. This paper from a recent Angewandte Chemie… Read More
  • Drug Assays

    The Basics of Phenotypic Screening

    I wanted to mention another paper from Nature Chemical Biology‘s recent special issue, this one on the best ways to run phenotypic screens. This area has been making a comeback in recent years (as discussed around here before), so articles like this are very useful to help people get up to speed – similar to… Read More
  • Drug Assays

    Good Ways To Mess Up Your Screening

    For those of you interested in fragment screening (and especially for those who are thinking of trying it out), Ben Davis of Vernalis and Dan Erlanson of Carmot Therapeutics have written an excellent guide to avoiding the common experimental problems. (Remarkably, at least to me, Elsevier has made this an open-access article). In fact, I’d… Read More
  • Chemical Biology

    The DNA-Encoded Library Platform Yields A Hit

    I wrote here about DNA-barcoding of huge (massively, crazily huge) combichem libraries, a technology that apparently works, although one can think of a lot of reasons why it shouldn’t. This is something that GlaxoSmithKline bought by acquiring Praecis some years ago, and there are others working in the same space. For outsiders, the question… Read More
  • Chemical News

    Automated Med-Chem, At Last?

    I’ve written several times about flow chemistry here, and a new paper in J. Med. Chem. prompts me to return to the subject. This, though, is the next stage in flow chemistry – more like flow med-chem: Here, we report the application of a flow technology platform integrating the key elements of structure–activity relationship (SAR) Read More
  • Drug Assays

    Getting Down to Protein-Protein Compounds

    Late last year I wrote about a paper that suggested that some “stapled peptides” might not work as well as advertised. I’ve been meaning to link to this C&E News article on the whole controversy – it’s a fine overview of the area. And that also gives me a chance to mention this review in… Read More
  • Chemical News

    Putting the (Hard) Chemistry Back in Med Chem

    While I’m on the subject of editorials, Takashi Tsukamoto of Johns Hopkins has one out in ACS Medicinal Chemistry Letters. Part of it is a follow-up to my own trumpet call in the journal last year (check the top of the charts here; the royalties are just flowing in like a river of gold, I… Read More