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Posts tagged with "Drug Assays"

  • Animal Testing

    The Animal Testing Hierarchy

    I’ve had some questions about animal models and testing, so I thought I’d go over the general picture. As far as I can tell, my experience has been pretty representative. There are plenty of animal models used in my line of work, but some of them you see more than others. Mice and rats are… Read More
  • Analytical Chemistry

    These Fragments I Have Shored Against My Ruins

    There’s been a big trend the last few years in the industry to try to build our molecules up from much smaller pieces than usual. “Fragment-based” drug discovery is the subject of many conferences and review articles these days, and I’d guess that most decent-sized companies have some sort of fragment effort going on. (Recent… Read More
  • Drug Assays

    A Bad Assay: Better Than None?

    Man, do we ever have a lot of assays in this business. Almost every drug development project has a long list of them, arranged in what we call a screening cascade. You check to make sure that your new molecule hits your protein target, then you try it on one or more living cell lines. Read More
  • Biological News

    Let Us Now Turn To the Example of Yo’ Mama

    Now we open the sedate, learned pages of Nature Methods, a fine journal that specializes in new techniques in molecular and chemical biology. In the August issue, the correspondence section features. . .well, a testy response to a paper that appeared last year in Nature Methods. “Experimental challenge to a ‘rigorous’ BRET analysis of GPCR… Read More
  • Cancer

    The Current Cancer Long-Jump Record

    As I’ve mentioned before, advances in molecular biology have continued to make all sorts of brute-force approachs possible – things that would have been laughed at (or, more likely, not even proposed at all) a few years ago. Another recent example of this is a paper earlier this year in Nature from the group of… Read More
  • Drug Assays

    Travels In Numerica Deserta

    There’s a problem in the drug industry that people have recognized for some years, but we’re not that much closer to dealing with it than we were then. We keep coming up with these technologies and techniques which seem as if they might be able to help us with some of our nastiest problems – Read More
  • Animal Testing

    Less Than Zero

    When I wrote about lousy animal models of disease a few days ago, there was a general principle at the back of my mind. (There generally is – my wife, over the years, has become accustomed to the sudden dolly-back panorama shots that appear unannounced in my conversation). It was: that a bad model system… Read More
  • Drug Assays

    No Shortcuts

    I wanted to link tonight to the “Milkshake Manifesto” over at OrgPrep Daily. It’s a set of rules for med-chem, and looking them over, I agree with them pretty much across the board. There’s a general theme in them of getting as close to the real system as you can, which is a theme I’ve… Read More
  • Cancer

    Good Mistakes?

    Here’s an interesting press release on a potential new class of anticancer drugs. It has a nice hook (“Lab mistake leads to cancer finding!”), and the work itself isn’t bad at all. It’s an neat biochemical result, which might eventually lead to something. You have to know a bit about drug discovery and development to… Read More
  • Clinical Trials

    Upside Down Activity

    After yesterday’s post, several people brought up the issue of inverted screening cascades. What happens when your compound works better in the mice than it did in the cells? Worse, what if it would have worked in the mice, but you never put it in there because it was so weak in the cell assays?… Read More
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