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Posts tagged with "Drug Assays"

  • Cancer

    The Current Cancer Long-Jump Record

    As I’ve mentioned before, advances in molecular biology have continued to make all sorts of brute-force approachs possible – things that would have been laughed at (or, more likely, not even proposed at all) a few years ago. Another recent example of this is a paper earlier this year in Nature from the group of… Read More
  • Drug Assays

    Travels In Numerica Deserta

    There’s a problem in the drug industry that people have recognized for some years, but we’re not that much closer to dealing with it than we were then. We keep coming up with these technologies and techniques which seem as if they might be able to help us with some of our nastiest problems – Read More
  • Animal Testing

    Less Than Zero

    When I wrote about lousy animal models of disease a few days ago, there was a general principle at the back of my mind. (There generally is – my wife, over the years, has become accustomed to the sudden dolly-back panorama shots that appear unannounced in my conversation). It was: that a bad model system… Read More
  • Drug Assays

    No Shortcuts

    I wanted to link tonight to the “Milkshake Manifesto” over at OrgPrep Daily. It’s a set of rules for med-chem, and looking them over, I agree with them pretty much across the board. There’s a general theme in them of getting as close to the real system as you can, which is a theme I’ve… Read More
  • Cancer

    Good Mistakes?

    Here’s an interesting press release on a potential new class of anticancer drugs. It has a nice hook (“Lab mistake leads to cancer finding!”), and the work itself isn’t bad at all. It’s an neat biochemical result, which might eventually lead to something. You have to know a bit about drug discovery and development to… Read More
  • Clinical Trials

    Upside Down Activity

    After yesterday’s post, several people brought up the issue of inverted screening cascades. What happens when your compound works better in the mice than it did in the cells? Worse, what if it would have worked in the mice, but you never put it in there because it was so weak in the cell assays?… Read More
  • Cancer

    Reality, Here In This Little Dish

    I’ve noticed a few stories making the rounds recently about possible new cancer therapies. Johns Hopkins has press-released the work of a group there on, and several news outlets have picked up on a British study on the effect of vanilloid agonists (such as the hot-pepper compound capsaicin) on cancer cells. And all this is… Read More
  • Drug Assays

    The Unattractive Truth

    “You like those scatterplots, don’t you?”, someone said to me the other day. And I can’t deny it. On most projects that my lab has been assigned to, at some point I end up messing around with all the project data, plotting one thing against another and looking for correlations. Often what I find is… Read More
  • Drug Assays

    Those Darn Invisible Creatures

    If you want to make your friends in the cell culture lab jump, just walk up behind them and shout “mycoplasma!” (What’s that? You say you have no friends in the cell culture lab? Hmm. . .) Mycoplasma is a scary word because they’re scary little organisms. They’re bacteria, just barely, running much smaller than… Read More
  • Drug Assays

    Waste O’ Time Awards

    Here’s a question for my readers in the research community: what assay have you dealt that turned out to be the biggest waste of time and effort? I can think of several strong nominees, but I’ll lead off with one from quite a while ago. This one happened in an antiviral group, and I believe… Read More