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Posts tagged with "In Silico"

  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More
  • Cancer

    An IBM-Watson Collaboration Goes Under

    I’ve written several times about IBM’s Watson machine learning system and its potential applications to health care. To be honest, many of these applications sound unlikely, at least at present, and that skepticism doesn’t apply only to IBM by any means. Now word comes that a collaboration between IBM and the M. D. Anderson peopl… Read More
  • In Silico

    The Flightosome

    I got this diagram from Arjun Raj‘s Twitter feed, and I think I enjoy it a bit more every time I see it. Some of that is because it’s a big part of what I was trying to get across in this column, but I think that the sketch does a more thorough job of… Read More
  • In Silico

    Unicorn Software for Drug Discovery

    So here’s the dream. You sit down at the keyboard and load a file of the structure of your new drug target – you’ve discovered that inhibition of Whateverase II or a ligand for the Type IV Whazzat receptor would be a good candidate for modifying some disease. You type out a few commands, and… Read More
  • In Silico

    Watson and Pfizer

    I have wondered several times around here about how (and if) IBM’s Watson platform is going to be able to help out with drug discovery, and it looks like we may be able to find that out. Pfizer has signed up with IBM to use the Watson technology in its immuno-oncology research. Here we go: Watson… Read More
  • Chemical News

    Nitration Isn’t So Simple

    OK, let’s get physical organic here for a little while. For atat ose outside the field, physical organic chemistry is the branch that studies how and why the reactions of organic chemistry happen – the details of which bonds break and form, in what order, in what arrangement, where the atoms and electrons are moving and… Read More
  • Chemical News

    David Weininger and Chemical Names

    David Weininger passed on last week, and you probably have to be into chemoinformatics for that name to immediately register. He came up with the SMILES notation for chemical structures, though, so that should make his contributions clear. Here’s an excellent appreciation by Anthony (“Ant”) Nicholls that will really give you a sen… Read More
  • Chemical News

    Calculating A Few Too Many New Compounds

    The phrase “automatic chemical design” will generally get my attention, especially when it’s applied to drug-like molecules. And that’s one the the key parts of this paper, from researchers at Harvard, Toronto, and Cambridge. From what I can see, they’re trying to come up with a new technique for generating potential n… Read More
  • Alzheimer's Disease

    The Limits of Big Data

    I fear that mentioning the phrase “Big Data” in the first sentence of a blog post will make half the potential readers suddenly remember that they have podiatrist appointments or something. But that’s the only way to approach this article at Wired. After all, the title is “The Cure For Cancer is Data – Mountains of… Read More
  • Cancer

    Better, Faster, More Comprehensive Manure Distribution

    So today brings news that Microsoft is working on curing cancer in the next five or ten years. That, I’m sure, will come as a relief, especially to those people who’ve had the company’s software crash on them recently. For some reason, the UK press is especially susceptible to Amazing Cancer Cure stories (and to… Read More