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Posts tagged with "Infectious Diseases"

  • Analytical Chemistry

    An HIV Structure Breakthrough? Or “Complete Rubbish”?

    Structural biology needs no introduction for people doing drug discovery. This wasn’t always so. Drugs were discovered back in the days when people used to argue about whether those “receptor” thingies were real objects (as opposed to useful conceptual shorthand), and before anyone had any idea of what an enzyme’s active sit… Read More
  • Cancer

    Stuart Schreiber at the Challenges in Chemical Biology Conference

    I’m listening to Stuart Schreiber make his case for diversity-oriented synthesis (DOS) as a way to interrogate biochemistry. I’ve written about this idea a number of times here, but I’m always glad to hear the pitch right from the source. Schreiber’s team has about 100,000 compounds from DOS now, all of which are searchable… Read More
  • Current Events

    One. . .Million. . .Pounds (For a New Antibiotic?)

    Via Stuart Cantrill on Twitter, I see that UK Prime Minister David Cameron is prepared to announce a prize for anyone who can “identify and solve the biggest problem of our time”. He’s leaving that open, and his examples are apparently “. . .the next penicillin, aeroplane or world wide web”. I like the idea… Read More
  • Infectious Diseases

    Sulfa Side Effects, Decades Later

    You’d think that by now we’d know all there is to know about the side effects of sulfa drugs, wouldn’t you? These were the top-flight antibiotics about 80 years ago, remember, and they’ve been in use (in one form or another) ever since. But some people have had pronounced CNS side effects from their use… Read More
  • Infectious Diseases

    A Little Ranbaxy Example

    Compare and contrast. Here we have Krishnan Ramalingam, from Ranbaxy’s Corporate Communications department, in 2006: Being a global pharmaceutical major, Ranbaxy took a deliberate decision to pool its resources to fight neglected disease segments. . .Ranbaxy strongly felt that generic antiretrovirals are essential in fighting the world-wide s… Read More
  • Infectious Diseases

    Another Germ Theory Victory – Back Pain?

    The “New Germ Theory” people may have notched up another one: a pair of reports out from a team in Denmark strongly suggest that many cases of chronic low back pain are due to low-grade bacterial infection. They’ve identified causative agents (Propionibacterium acnes) by isolating them from tissue, and showed impressive success in… Read More
  • Drug Development

    Does Baldness Get More Funding Than Malaria?

    OK, let’s fact-check Bill Gates today, shall we? Capitalism means that there is much more research into male baldness than there is into diseases such as malaria, which mostly affect poor people, said Bill Gates, speaking at the Royal Academy of Engineering’s Global Grand Challenges Summit. “Our priorities are tilted by marketplac… Read More
  • In Silico

    IBM’s Watson Does Drug Discovery?

    I saw this story this morning, about IBM looking for more markets for its Watson information-sifting system (the one that performed so publicly on “Jeopardy”. And this caught my eye for sure: John Baldoni, senior vice president for technology and science at GlaxoSmithKline, got in touch with I.B.M. shortly after watching Watson’s “J… Read More
  • Animal Testing

    Mouse Models of Inflammation Are Basically Worthless. Now We Know.

    We go through a lot of mice in this business. They’re generally the first animal that a potential drug runs up against: in almost every case, you dose mice to check pharmacokinetics (blood levels and duration), and many areas have key disease models that run in mice as well. That’s because we know a lot… Read More
  • Infectious Diseases

    Three Rings in a Row

    Here’s a structure that caught me eye, in this paper from Georgia State and Purdue. That’s a nice-looking group stuck on the side of their HIV protease inhibitor; I don’t think I’ve ever seen three fused THF rings before, and if I have, it certainly wasn’t in a drug candidate. From the X-ray structure, it… Read More
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