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Posts tagged with "Infectious Diseases"

  • Infectious Diseases

    Do It Again

    This is the 50th anniversary year of the announcement of Jonas Salk’s polio vaccine, as you’ve probably been noticing. There a new book out on the discovery, and plenty of newspaper and magazine articles. I’ll save comment on the vaccine (and Salk himself) for another time. What got me thinking was an incident during the… Read More
  • Infectious Diseases

    An Antiviral Example

    I mentioned yesterday that sometimes you can find an antiviral target that doesn’t depend on what the virus itself has to offer. As fate would have it, there are a few drugs coming along that use just such a mechanism against HIV. They’re based on their affinity toward a protein called CCR5, which sits straddling… Read More
  • Infectious Diseases

    Can Med-Chem Help With Bird Flu?

    If avian flu does gain a foothold in humans, what can drug companies do about it? (This should give you the latest headlines on the disease.) It’s definitely something to worry about. There hasn’t been a real rampager of a flu epidemic in a long time, and a pessimist would say that we’re overdue. The… Read More
  • Infectious Diseases

    Empty Shelves

    Yesterday I was writing about a proposal to encourage new antibiotics, partly by not putting so much effort into discouraging the use of the current ones. The economist who’s advocating this, Paul Rubin, also would like for the FDA to consider accelerating the approval process (and at the very least, not making it even harder… Read More
  • Infectious Diseases

    Resistance to Resistance

    Forbes has an article on some recent work of Paul Rubin, an economist at Emory. He’s looking at the situation in approvals of new antibiotic drugs, which isn’t an encouraging sight. He’s of the opinion that too much government effort has gone into cutting overuse of the existing drugs (to try to slow down the… Read More
  • Biological News

    It’s a Bacterial Planet, You Know

    You’ve probably heard of the hypothesis that a reasonable amount of dirt is good for you, especially in childhood. (My kids are certainly taking no chances.) The idea is that the immune system needs a certain amount of challenge to develop properly, so trying to live too antiseptic a life is a mistake. I think… Read More
  • Infectious Diseases

    They Will Do Such Things. . .

    I see that Steven den Beste linked to me as a general source of med-chem info, which was good of him. He was discussing resistance in treatment of tuberculosis (on the way to a broader point about current events), so I thought I’d say a few words about antiinfective drugs. As I’ve mentioned in the… Read More
  • Infectious Diseases

    A Last-Ditch Effort – Or Is It?

    There’s a rather weird legal fight going on between Glaxo SmithKline and the rest of the world. Like everyone else, GSK is fighting to hold on to profitable drugs that are losing patent protection. A lot of. . .creative. . .arguments are being deployed in these efforts, and I can’t figure out if this is… Read More
  • Infectious Diseases

    Better Them Than Me

    Roche and their partner, Trimeris are developing an anti-HIV compound (called T-20) that has some remarkable features. It’s the first to target a cell protein (gp-41) that is a key binding step in HIV’s mode of infection, for one thing. But to be more precise, it has 106 more interesting things about it – that’s… Read More
  • Drug Development

    A Twisty Road

    The business news has been on top of the science news recently, that’s for sure. Maybe we can go a week or so without accounting issues, mergers, and whatnot. I wanted to call people’s attention to a good article in July 8 issue of The Scientist (free, but registration required.) It’s a history of a… Read More