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Posts tagged with "Infectious Diseases"

  • Chemical Biology

    Tagging Fungi For Destruction

    Fungal infections can be very bad news when they go beyond the get-something-from-the-drugstore stage. That fact that a drug as rough as amphotericin B is still in use is evidence enough of that. There’s definitely a need for new ideas in the antifungal area, but drug discovery there has been tough. This new paper, though… Read More
  • Infectious Diseases

    More Bacterial Targets Than You Know

    Do you want to find new drugs treat human bacterial infections? (If you don’t, you’d better hope that someone else does!) The standard view in the field has long been that you have to target some essential pathway in those bacteria, one that doesn’t have a counterpart in human biology (or whose sequence and structure… Read More
  • Drug Industry History

    Where MRSA Came From

    OK, everyone recognizes the problem that we face with drug-resistant bacteria. MRSA (methicillin-resistant Staphylococcus aureus) is the most well-known variety, and it’s bad news. Penicillin was introduced in the 1940s, and methicillin was brought to market in 1959, largely because so many infections were becoming resistant to penicillin by… Read More
  • Drug Development

    A Long Journey to the Capsid

    There’s a fine article at C&E News on Gilead’s capsid inhibitor for HIV. For those not into virology, the capsid is the protein coat that viruses have – it’s their armor, more or less, and disrupting its formation should be a large problem for them. But finding compounds that accomplish that is a large problem… Read More
  • Infectious Diseases

    A New Antibiotic Class, Which You Don’t Get to Say Very Often

    Never say never. Screening natural product extracts for new antibiotics has been a diminishing-returns exercise for quite a while now, which is too bad, since basically every single important antibiotic class came via that route originally. Bacteria compete with each other (as do plenty of other organisms), and seeing what they’ve come up wit… Read More
  • Chemical News

    Antibiotic Progress – And Not a Moment Too Soon

    Anyone who’s done antibiotic research can tell you about what a slog it is. Just looking at the rate of approval of new ones will tell you that, too – it really is like breaking rocks, except breaking rocks is a lot more straightforward and rewarding most of the time. As I’ve said before, when… Read More
  • Infectious Diseases

    The Invisible Fight for Iron

    One of the things that I have always liked about the sciences is that you get a behind-the-scenes look at what’s really going on in the world (which is something I emphasized in various entries in The Chemistry Book). If you’re not a biologist or chemist, one of those little-known but crucial things is how much… Read More
  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More
  • Drug Assays

    The Weirdness of Ebselen

    I think that most medicinal chemists look at the structure of ebselen and say “That’s not a drug”. Selenium atoms don’t belong in drugs, we figure, and Se-N bonds most certainly don’t. But it stands as a rebuke to our intuitions, because it’s been kicking around in the clinic for some time (and has certainly… Read More
  • Clinical Trials

    Antibiotics Are Hard, Continued

    I wrote here about an ingenious synthetic effort into structurally diverse ketolide antibiotics, structures that need a lot of work to make them from the ground up. Well, I have one of those good-news/bad-news reports: it looks like synthetic work will definitely be needed in this area, because the latest clinical candidate in it has… Read More
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