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Posts tagged with "Infectious Diseases"

  • Infectious Diseases

    The Invisible Fight for Iron

    One of the things that I have always liked about the sciences is that you get a behind-the-scenes look at what’s really going on in the world (which is something I emphasized in various entries in The Chemistry Book). If you’re not a biologist or chemist, one of those little-known but crucial things is how much… Read More
  • Biological News

    The Microbiome and Human Obesity: Wait a Minute

    For the last few years, it has been impossible to escape talk of the microbiome – the associated bacteria (and other organisms) that live in and on the human body. Overall, this attention has been a good thing, since it’s made people aware of just how bacteria-laden we are (not that everyone finds that a… Read More
  • Drug Assays

    The Weirdness of Ebselen

    I think that most medicinal chemists look at the structure of ebselen and say “That’s not a drug”. Selenium atoms don’t belong in drugs, we figure, and Se-N bonds most certainly don’t. But it stands as a rebuke to our intuitions, because it’s been kicking around in the clinic for some time (and has certainly… Read More
  • Clinical Trials

    Antibiotics Are Hard, Continued

    I wrote here about an ingenious synthetic effort into structurally diverse ketolide antibiotics, structures that need a lot of work to make them from the ground up. Well, I have one of those good-news/bad-news reports: it looks like synthetic work will definitely be needed in this area, because the latest clinical candidate in it has… Read More
  • Biological News

    Is Selective Ribosome Stalling Possible? Apparently So

    PCSK9 is a drug target that’s famous in several directions. If you’re interesting in human genetics, it’s famous as an example of a “human knockout” – people with nonfunctional PCSK9, and there are a handful, have extraordinarily low levels of LDL, a finding that immediately got drug companies interested in findi… Read More
  • Cancer

    More Than Was Asked For

    Via AndyBiotech on Twitter, here’s an interesting report from the New England Journal of Medicine. It describes a patient diagnosed with follicular lymphoma who also was positive for hepatitis C. They went through a course of Gilead’s sofosbuvir with ribavirin, and that (as it usually does) cleared the Hep C infection. What’s inte… Read More
  • Biological News

    Another Bad Effect of Antioxidant Supplements

    It’s been increasingly clear that the widespread marketing of antioxidants as vital health-giving nutrients is often mistaken. Taking antioxidants reduces the cellular effects of exercise, and interferes with many forms of cancer treatment (both of which effects are exactly the opposite of the popular conceptions of what should be happening). Read More
  • Alzheimer's Disease

    Bill Gates and His Moonshot

    The rocket’s supposed to be moving, and it probably is, but everyone knows that you can’t see that with the naked eye. Not at first. The announcer said “Lift-off” – well, that probably happened sometime during the lunch hour, it’s easy to miss – and the first thing you look for is the exhaust starting… Read More
  • Business and Markets

    More from the Drugs for Neglected Disease Initiative

    My recent post on the Drugs for Neglected Diseases Initiative (DNDi) brought some emails from Robert Don at the organization. He has more details on the sleeping sickness project – pointing out, for example, that the contribution from Scynexis was not pro bono, as I’d assumed: We actually contracted a team of 10 chemists at… Read More
  • Drug Development

    The Open Source Malaria Project, So Far

    The Open Source Malaria (OSM) project has a paper out (open-access, fittingly) in ACS Central Science, and it’s an interesting read. This is the effort from Mat Todd at Sydney and many, many others around the world to build on the malaria phenotypic screening results released in 2010 (and prioritized in 2011) by GSK. They’ve been foll… Read More