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Posts tagged with "Infectious Diseases"

  • Biological News

    Is Selective Ribosome Stalling Possible? Apparently So

    PCSK9 is a drug target that’s famous in several directions. If you’re interesting in human genetics, it’s famous as an example of a “human knockout” – people with nonfunctional PCSK9, and there are a handful, have extraordinarily low levels of LDL, a finding that immediately got drug companies interested in findi… Read More
  • Cancer

    More Than Was Asked For

    Via AndyBiotech on Twitter, here’s an interesting report from the New England Journal of Medicine. It describes a patient diagnosed with follicular lymphoma who also was positive for hepatitis C. They went through a course of Gilead’s sofosbuvir with ribavirin, and that (as it usually does) cleared the Hep C infection. What’s inte… Read More
  • Biological News

    Another Bad Effect of Antioxidant Supplements

    It’s been increasingly clear that the widespread marketing of antioxidants as vital health-giving nutrients is often mistaken. Taking antioxidants reduces the cellular effects of exercise, and interferes with many forms of cancer treatment (both of which effects are exactly the opposite of the popular conceptions of what should be happening). Read More
  • Alzheimer's Disease

    Bill Gates and His Moonshot

    The rocket’s supposed to be moving, and it probably is, but everyone knows that you can’t see that with the naked eye. Not at first. The announcer said “Lift-off” – well, that probably happened sometime during the lunch hour, it’s easy to miss – and the first thing you look for is the exhaust starting… Read More
  • Business and Markets

    More from the Drugs for Neglected Disease Initiative

    My recent post on the Drugs for Neglected Diseases Initiative (DNDi) brought some emails from Robert Don at the organization. He has more details on the sleeping sickness project – pointing out, for example, that the contribution from Scynexis was not pro bono, as I’d assumed: We actually contracted a team of 10 chemists at… Read More
  • Drug Development

    The Open Source Malaria Project, So Far

    The Open Source Malaria (OSM) project has a paper out (open-access, fittingly) in ACS Central Science, and it’s an interesting read. This is the effort from Mat Todd at Sydney and many, many others around the world to build on the malaria phenotypic screening results released in 2010 (and prioritized in 2011) by GSK. They’ve been foll… Read More
  • Drug Assays

    Zika Cures? Not Quite Yet

    There’s a paper out in Nature that’s gotten a lot of attention, because it’s directed towards therapies against Zika virus infection. The authors (a multi-center team) screening a library of existing drugs, known active pharmacological agents and tools, clinical candidates, etc. in a caspase-3 assay, since they’d recently fo… Read More
  • Business and Markets

    Gosh, Fellows, There’s a Better Way

    I wrote a few months ago about the Drugs for Neglected Diseases Initiative (DNDI) and how some people have pointed to its low costs as a new model for drug discovery. I wasn’t convinced. Now there’s a long article at Nature News (update: link fixed) about the DNDI and how its low costs could be a… Read More
  • Infectious Diseases

    Three Diseases at Once?

    Here’s a really nice paper that points out a possible way to attack three terrible parasitic diseases at the same time: Chagas disease, leishmaniasis, and sleeping sickness, all caused by related protozoan organisms. This new effort, a multicenter collaboration between labs at Novartis, York, Washington, and the Wellcome Trust labs at Glasgow… Read More
  • Infectious Diseases

    New Antibiotics, Potential and (Nearly) Actual

    Some antibiotic news today: first off, there’s a new multinational collaboration (CARB-X) to work on drug-resistant bacteria. Among other things, it’ll be giving grants to small companies in the US and Europe who are working in the area. They’re especially targeting new varieties of compounds, rather than variations on existing sc… Read More