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Posts tagged with "Life in the Drug Labs"

  • Chemical News

    Simple Rings, Simply Wrong

    Medicinal chemists spend a lot of time thinking about the relative greasiness of their molecules. Being professional scientists, of course, we have come up with some slightly more quantitative phrases than “relative greasiness”, but that’s definitely the idea. How hydrophilic/hydrophobic a compound is determines not to what extent… Read More
  • Life in the Drug Labs

    Med-Chem Labs: What’s Changed?

    Traveling today, so not much time for a full-scale post. But I wanted to toss out a question to my fellow medicinal chemists instead. I was talking with some colleagues the other day, including a couple of people who’d been around for a while, and we were discussing what things med-chemists used to spend more… Read More
  • Drug Development

    On Jadedness

    It’s a Friday in midsummer, so I assume that a fair percentage of the readership is not even around! So I’m not going to do a huge detailed blog post (got one of those coming on Monday, actually). Today I just wanted to go on a bit about a problem that comes with experience in… Read More
  • Business and Markets

    That Other Kind of Job

    This tweet by ChemJobber caught my eye over the weekend. He’s referencing an article in the New Yorker on “The Bullshit-Job Boom”, which is a review of this new book by David Graeber at the London School of Economics. Graeber’s thesis is that there is a higher and higher fraction of the labor market occupied… Read More
  • Drug Development

    How to Be a Good Medicinal Chemist

    Longtime medicinal chemist Mark Murcko has a Perspective article out in J. Med. Chem. on “What Makes a Great Medicinal Chemist“. As he makes clear from the beginning, if you’ve been doing this stuff for a while, you’ve likely heard many of these recommendations before. But it’s useful for people starting out, and it… Read More
  • Drug Assays

    Thoughts on Compound Collections

    I’ve recently had similar questions from two different people (on two different coasts) about screening collections and compound libraries, so it seems like it could be a topic of interest. So far I have yet to come across a drug discovery organization that really thinks that its compound libraries are what they should be – Read More
  • Drug Assays

    One Way to Find Out

    Here’s a thing about research (and drug discovery in particular) that makes it a bit different from many other occupations: you can go for extended periods without even being sure that you’re doing what you’re supposed to be doing. This thought came to mind yesterday when (on Twitter) Ash Jogalekar quoted a biotech veteran as… Read More
  • Life in the Drug Labs

    Chemicals, Shelves and Shelves of Them

    My mention yesterday of the number of starting materials needed for drug synthesis prompted a reader outside the industry to ask just how many I might be talking about, and how these things are managed. I looked over the paper being discussed, just for an example, and for its three drug syntheses it needed a… Read More
  • Life in the Drug Labs

    Now, Let’s See. . .

    As you can tell, it’s been quiet around here! I’m living up to the recipes I’ve published on the blog this time of year, though – I made the chicken pot pie last night, and it was a good night to stay indoors and eat it, since it got down to -4F around here. Soon… Read More
  • Chemical News

    Extraction and Salting-Out

    I really enjoyed this paper, because it goes into detail on a technique that organic bench chemists the world over have all used at some point: “salting out”. I’ll go into some background for the nonchemists for a few paragraphs and then return to the paper itself, which all working organic chemists should have a… Read More
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