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  • The Real Hazards of the Lab

    A run of bad accident news today, and all of the same kind. The Chemistry Blog has the story of a fatality in the labs at UCLA. The short and painful details ar… Read More
  • Lack of Experience, You Know

    OK, solid chemistry around here today. It looks as if I’ll be running a ring-closing metathesis reaction soon. Nobel Prize in 2005, all over the chemistry… Read More
  • Poor Equipment Revisited

    A colleague came by a while ago and said “You know, the comments to that last post of yours are in danger of turning into Monty Python’s Four Yorksh… Read More
  • The Perils of Poor Equipment

    The late Peter Medawar once wrote about resources and funding in research, and pointed out something that he thought did a lot more harm than good: various roma… Read More
  • Out the Door and Down the Stairs

    I’ve noticed over the years that my patience in seminars and talks has been eroding. This started in graduate school – I certainly sat through my share of l… Read More
  • Fearful Symmetry?

    It’s worth examining your own scientific prejudices and biases from time to time, to see if they’re still valid. Of course, that begins with the difficult t… Read More
  • Old School – Really Old

    We try to be delicate when we synthesize our molecules – really, we do. Delicate reactions often have better yields and fewer side products. Exotic catalysts… Read More
  • Why Don’t You Just. . .

    For the most part, the biologists on a drug discovery project expect us in the med-chem labs to be able to make pretty much anything we need to make. Actually,… Read More
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