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Posts tagged with "Life in the Drug Labs"

  • Life in the Drug Labs

    How Good (or Bad?) Are Patent Procedures, Anyway?

    All the comments on the Lundbeck / Dr. Reddy’s imbroglio got me to thinking: how good are patent procedures, anyway? I said in that earlier post that I didn’t think that they were that much different from procedures in the open literature, but I’d like to throw the issue open for comment. You might think… Read More
  • Life in the Drug Labs

    Hot Chemistry, Low Tech to High

    Time for some lab talk. There are usually a number of different ways to attack a given problem in organic chemistry. You go with what you know, or what looks most likely to work, or what you actually have the equipment (or funds) to realize. This range of choices goes all the way down to… Read More
  • Life in the Drug Labs

    Inspiration Is Where You Find It

    Have you ever worked for a company with its own corporate anthem? It would probably have to be a fairly large outfit; I don’t think a smaller shop would be able to afford such a thing, even if they somehow decided that they needed one. (Here’s some advice: if your small or medium-sized company rolls… Read More
  • Drug Assays

    Structure-Activity: Lather, Rinse, and Repeat

    Medicinal chemists spend a lot of their time exploring and trying to make sense of structure-activity relationships (SARs). We vary our molecules in all kinds of ways, have the biologists run them through the assays, and then sit down to make sense of the results. And then, like as not, we get up again after… Read More
  • Life in the Drug Labs

    The Limits of Free Scientist Chow?

    This piece over at Science magazine’s “The Gonzo Scientist”, brought back some memories. John Bohannon, in the midst of an investigation of truffles, tried an experiment on some party guests: rank a series of five patés according to taste. There were three authentic ones, two fake ones (liverwurst and whipped Spam), and. . .dog f… Read More
  • Life in the Drug Labs

    Supplies of Suppliers

    When I joined the Wonder Drug Factory in late 1997, you still had to buy chemicals by writing down the name and catalog number on a form (and press hard; it was one of those multicolor triplicates). I thought that was pretty primitive then, since at my previous company we’d already gone to electronic ordering… Read More
  • Life in the Drug Labs

    Prep TLC: The Good Old Days Live On

    I did something in the lab the other day that I hadn’t done in several years: run some preparative TLC plates. I had some small reactions that needed to be cleaned up, and the HPLC systems were all in use, so I thought “Why not?” (I wrote here about the decline of analytical TLC in… Read More
  • Life in the Drug Labs

    Fancy Building, Fancy Science?

    I see that there’s a new biochemistry building at Oxford, written up here in Nature. It was designed by a London architectural firm, Hawkins\Brown (love that backslash, guys, so very modern of you), and according to the article, the design: ”. . .ensures that the 300 researchers working there communicate as much as possible. The… Read More
  • Chemical News

    The Real Hazards of the Lab

    A run of bad accident news today, and all of the same kind. The Chemistry Blog has the story of a fatality in the labs at UCLA. The short and painful details are: inexperienced student, t-butyllithium, flammable clothing, and panic (as in not running toward the safety shower). This is very sad to hear about… Read More
  • Life in the Drug Labs

    Lack of Experience, You Know

    OK, solid chemistry around here today. It looks as if I’ll be running a ring-closing metathesis reaction soon. Nobel Prize in 2005, all over the chemistry journals for years. . .and I’ve never had occasion to use one until now. And when I think about it, there are quite a few other reactions in that… Read More