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Posts tagged with "Life in the Drug Labs"

  • Life in the Drug Labs

    What Structures Have Turned on You?

    When you ask a bunch of medicinal chemists to look over a list of structures – screening hits, potential additions to the compound collection, that sort of thing – you’ll find that everyone will cross some of them off. But the agreement between the chemists on which ones need to go, that’s the tough part. Read More
  • Drug Development

    How to Run a Drug Project: Are There Any Rules at All?

    Here’s an article from David Shayvitz at Forbes whose title says it all: “Should a Drug Discovery Team Ever Throw in the Towel?” The easy answer to that is “Sure”. The hard part, naturally, is figuring out when. You don’t have to be an expensive management consultant to realize that it would be helpful for… Read More
  • Life in the Drug Labs

    Absence Makes the Ideas Flow?

    Something I’ve noticed for many years now is that I tend to get the most number of chemical ideas – bench chemistry relating to my current work – when I’m in a big conference room far removed from my actual lab. Take me off site, send me to a distant meeting, and I get all… Read More
  • Life in the Drug Labs

    That’s Just Too Colorful

    I have just made the most eyewateringly fluorescent orange compound of my entire chemical career. It’s not in a structural class that normally I would be exploring, but it’s been a while since I was on a normal project, so that’s fine. But this thing – yikes. I keep telling myself “It’s a probe, it’s… Read More
  • Life in the Drug Labs

    This All Too Open Office

    Many of you will have seen this article in C&E News on open-plan offices. Its author, Alex Scott, got in touch with me while writing it, and there are a lot of interesting things in it. But as Chemjobber says here, some of the claims that Scott’s interviewees make are a bit hard to believe. Read More
  • Life in the Drug Labs

    How Many Elements Have You Used, As Elements?

    I’ve written before about how many different elements I’ve used over the course of my chemical career, but here’s a more demanding variant of that question: how many elements have you used in their elemental form? Here’s my list – I’m including things that have been transformed, and some that haven’t, but I… Read More
  • Chemical News

    Gitcher SF5 Groups Right Here

    I think that several of us in medicinal chemistry have been keeping our eyes out for a chance to work in a pentafluorosulfanyl (SF5) group. I know I have – I actually have a good-sized folder on the things, and some of the intermediates as well, but I’ve never found the right opportunity. Yeah, I… Read More
  • Chemical News

    The Bread Rolls of Synthesis

    Over at Colorblind Chemistry, I came across a quote from Fritz Haber, writing about his thesis work: The thesis is miserable. One and a half years of new substances prepared like baker’s bread rolls… and in addition, lots of negative results just where I was looking for significant results, and further, results that I cannot… Read More
  • Life in the Drug Labs

    “The Time Had Now Come to Attempt the First Large-Scale Reaction. . .”

    Here’s a look at the life of a process/scale-up chemist while trying to get a key reaction to fly right. This is just the sort of problem these people deal with all the time – time pressure, troublesome reagent sourcing, purity and workup problems. And there’s no place to hide, because you’re always working on… Read More
  • Life in the Drug Labs

    Beelzebub Pharma, Inc.

    I wanted to note my latest column for the RSC’s Chemistry World, because I thought many readers here would be able to relate to it. I have a series of proposals for running the worst drug discovery organization I can think of – a set of simple rules that I think would bring things to… Read More