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  • Modifying Natural Products, And How

    The field of late-stage modification of complex structures has seen several advances in the last few years, and this is just the sort of thing that medicinal ch… Read More
  • Curcumin Will Waste Your Time

    I really enjoyed reading this article in J. Med. Chem. on curcumin. (Update: here’s the take over at Practical Fragments). That’s a well-known natur… Read More
  • Maoecrystal V: You Poor People

    The virtues and shortcomings of total synthesis are both on display in this new paper from the Baran group at Scripps, “Total Synthesis of Maoecrystal V&# Read More
  • Antibiotics: Not As Easy As They Say

    Since we were just talking yesterday about antibiotics and the misconceptions that people have about them, this is an appropriate time to take a look at an arti… Read More
  • Screen Carefully

    This recent paper asks the question “Can Invalid Bioactives Undermine Natural-Product Based Drug Discovery?” And as any of you who’ve done any… Read More
  • The Case For Non-Biogenic Tramadol

    The battle over whether tramadol is a natural product or not has been a heated one. Over the last couple of years, it was reported to be produced by a west Afri… Read More
  • The Tramadol Wars

    You may recall the report of the synthetic analgesic tramadol as a natural product from Cameroon, and the subsequent report that it was nothing of the kind. (Th… Read More
  • Speaking of Polyphenols. . .

    Yesterday’s mention of “nightmare polyphenols” prompted a reader to ask about the one in this paper. That’s it over there at the left, a… Read More
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