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  • Screen Carefully

    This recent paper asks the question “Can Invalid Bioactives Undermine Natural-Product Based Drug Discovery?” And as any of you who’ve done any… Read More
  • The Case For Non-Biogenic Tramadol

    The battle over whether tramadol is a natural product or not has been a heated one. Over the last couple of years, it was reported to be produced by a west Afri… Read More
  • The Tramadol Wars

    You may recall the report of the synthetic analgesic tramadol as a natural product from Cameroon, and the subsequent report that it was nothing of the kind. (Th… Read More
  • Speaking of Polyphenols. . .

    Yesterday’s mention of “nightmare polyphenols” prompted a reader to ask about the one in this paper. That’s it over there at the left, a… Read More
  • How Polyphenols Work, Perhaps?

    No medicinal chemist, in my experience, is enthusiastic about polyphenol compounds. At least, not after their first experiences with them. These things are all… Read More
  • Mix-and-Match Natural Products

    A lot of people in med-chem and chemical biology would like to have more natural-product-like features in their libraries of organic compounds. But realizing th… Read More
  • Hit the Polyamine Pedal, And Hold It

    As part of the no-doubt-endless series of head-shaking natural product structures out there, allow me to present the newly described Protoaculeine B, isolated f… Read More
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