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Posts tagged with "Natural Products"

  • Natural Products

    Hit the Polyamine Pedal, And Hold It

    As part of the no-doubt-endless series of head-shaking natural product structures out there, allow me to present the newly described Protoaculeine B, isolated from an Okinawan marine sponge. That side chain looks as if it were inspired by listening to Philip Glass, and it fits well into the category of “I never would have made… Read More
  • Natural Products

    Tramadol Turns Out to Be a Natural Product

    Every so often reports appear that some synthetic compound actually turns out to be a natural product. Sometimes these make very little sense, and turn out to be analytical mistakes (as with this report of nevirapine). But sometimes they’re right. This one looks as if it’s right, though. Nauclea latifola, known colloquially as the ̶… Read More
  • Chemical Biology

    Making the Bacteria Make Your Fluorinated Compounds

    Acetate is used in vivo as a starting material for all sorts of ridiculously complex natural products. So here’s a neat idea: why not hijack those pathways with fluoroacetate and make fluorinated things that no one’s ever seen before? That’s the subject of this new paper in Science, from Michelle Chang’s lab at Berkeley. The… Read More
  • Biological News

    More on Warp Drive Bio and Cryptic Natural Products

    At C&E News, Lisa Jarvis has an excellent writeup on Warp Drive Bio and the whole idea of “cryptic natural products” (last blogged on here). As the piece makes clear, not everyone even is buying into the idea that there’s a lot of useful-but-little-expressed natural product chemical matter out there, but since there could be… Read More
  • Chemical News

    Ingenol: A Walk In The Park

    The Baran group at Scripps has a whopper of a total synthesis out in Science. They have a route to the natural product ingenol, which is isolated from a Euphorbia species, a genus that produces a lot of funky diterpenoids. A synthetic ester of the compound as recently been approved to treat actinic keratosis, a… Read More
  • Biological News

    More From Warp Drive Bio (And Less From Aileron?)

    There hasn’t been much news about Warp Drive Bio since their founding. And that founding was a bit of an unusual event all by itself, since the company was born with a Sanofi deal already in place (and an agreement for them to buy the company if targets were met). But now things seem to… Read More
  • Drug Assays

    Protein-Protein Compounds – The Flip Side

    The topic of protein-protein inhibitor compounds has come up around here several times. It’s the classic “undruggable” target, although that adjective isn’t quite accurate. Let’s leave it at “definitely harder than the usual stuff”; no one could argue with that. But there’s a flip side to this area th… Read More
  • Analytical Chemistry

    Picking Out Incorrect Natural Products

    Once in a while, you see people who’ve gone to the trouble of synthesizing a natural product, only to find that its structure had been incorrectly assigned. (Back in the days when structure elucidation was much harder, R. B. Woodward had this on his list of reasons to do total synthesis, although it wasn’t number… Read More
  • Chemical Biology

    Forcing Fungi to Make Stranger Compounds

    Natural products come up around here fairly often, as sources of chemical diversity and inspiration. Here’s a paper that combines them with another topic (epigenetics) that’s been popular around here as well, even if there’s some disagreement about what the word means. A group of Japanese researchers were looking at the natural pr… Read More
  • Chemical News

    A Total Synthesis Archive

    For those who are into total synthesis of natural products, Arash Soheili has a Twitter account (Total_Synthesis) that keeps track of all the reports in the major journals. He’s emailed me with a link to a searchable database of all these, which brings a lot of not-so-easily-collated information together into one place. Have a look! Read More
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