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Posts tagged with "The Central Nervous System"

  • Alzheimer's Disease

    The Genomics of Neurons. And Alzheimer’s. And Everything Else.

    The brain is a complicated organ. Let’s start there. It’s complicated at every level that you care to examine, and if you get down to the genomic sequences of individual neurons, it’s worse than ever. The sheer variety of neurons and other cell types is quite extreme, and a lot of work over the years… Read More
  • Biological News

    Real Progress in Parkinson’s

    There have been some potentially significant developments in Parkinson’s disease, which is a good thing to be able to report. As populations age around the world, PD has been on its way up, but therapies for it have not been, despite a good deal of work in the field. But it looks like some clues… Read More
  • Biological News

    Sunlight And the Brain

    One of the impressive things about biochemistry and cell biology is how it can produce physical correlates to things that we know and experience, but have no detailed explanation for. There’s a really interesting example out in Cell that has to do with the effects of sunlight on mood and learning. Those effects are real, but… Read More
  • Alzheimer's Disease

    The Case of Verge Genomics

    A number of people have passed along the recent press stories about Verge Genomics, a new company out of YCombinator that has just raised $32 million for neuroscience drug discovery. Now that, as literally anyone who’s ever done it can tell you, is a hard field of a hard field, and I wish Verge good… Read More
  • Analytical Chemistry

    The Phosphoproteomic Landscape Speaks – What Did It Say, Again?

    Medicinal chemists are extremely familiar with G-protein coupled receptors (GPCRs), and it’s a safe bet that any pretty much any neurotransmitter (for example) that can be named by the general public is a GPCR ligand, too. Serotonin, dopamine, histamine – all the classics are there, and that’s reflected in the number of marketed d… Read More
  • The Central Nervous System

    A Molecular Mechanism for Alcoholism?

    If this works out, it’s something that people have been trying to find for a long time: what exactly are the genetic/biochemical vulnerabilities that make a person susceptible to alcoholism? It’s long been suspected that there must be some, but untangling these things from sheer behavioral/environmental effects is extremely difficult. I… Read More
  • Alzheimer's Disease

    Alzheimer’s and Infectious Disease: For Real

    I’ve written a couple of times over the years about the idea that Alzheimer’s disease might have an infectious component to it. That’s been proposed many times, but it’s fair to say that it’s never caught on. For one thing, the amyloid hypothesis has always had a lot more going for it. I realize that… Read More
  • Business and Markets

    Welcome to Right to Try

    Update: Brainstorm has now abandoned their Right-to-Try approach. Who’s next? That didn’t take long. That didn’t take long at all. The federal “Right to Try” bill was just signed the other week, and we already have a company that’s willing – no, eager – to try it out. I will now cruelly caricature som… Read More
  • Drug Assays

    Tecfidera Explained

    One of the more unusual drugs on the market is Tecfidera (dimethyl fumarate). I went into its history a bit in this post, if you’re wondering how a molecule that small and unfunctionalized became a multiple sclerosis drug. As that shows, it went into trials for the disease with quite a bit of clinical rationale… Read More
  • The Central Nervous System

    Understanding Antidepressants – Or Not

    I was talking with a colleague the other day who’s done a lot of work on central nervous system disease over the years, and it reminded me of something that I said years ago on this blog (and was the first time I was quoted in the Wall Street Journal). Was that an opinion about… Read More
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