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Posts tagged with "The Central Nervous System"

  • Autism

    Thimerosal. Again.

    Yet another study has shown no link between the former vaccine additive thimerosal and neurological problems in children. This one evaluated over a thousand seven-to-ten year olds for a long list of outcomes, and came up negative. No strong correlations were found, and the weak ones seemed to spread out evenly among positive and negative… Read More
  • Clinical Trials

    Rimonabant: Down to Earth

    Everyone will have heard the news about Wednesday’s FDA Advisory Commitee vote on Accomplia / Zimulti (rimonabant). If you’d tried to convince folks a few years ago that this drug wouldn’t make it to a vote until summer of 2007, and would be unanimously rejected when it did, you’d have been looked at with pity… Read More
  • Cardiovascular Disease

    Rimonabant, Out In the Light

    The FDA briefing documents for Wednesday’s discussion of Accomplia / Zimulti (rimonabant) have been posted, and they’re an interesting read indeed. As everyone in the industry knows, this drug was once looked on as the next potential record-breaker, and writing the first part of this sentence in that verb form tells you a lot about… Read More
  • Alzheimer's Disease

    Failure: Not Your Friend, But Definitely Your Companion

    Here’s something that you don’t see discussed very often, but it’s worth some thought: what kind of personality do you need to have to do drug discovery research? Clearly, any conclusions are going to carry over well to other fields, but drug work has some peculiarities that can’t be ignored. The most obvious one is… Read More
  • Business and Markets

    Schering-Plough Goes Shopping

    Schering-Plough woke everyone up with a large surprise bid for Organon, the long-suffering pharmaceutical arm of Akzo Nobel. Many people are spinning this as a good deal for everyone involved, and that may be. But then again, people always seem to say that about mergers and buyouts, and they’re not always right, are they? Organon… Read More
  • Current Events

    CMPI Conference: Critical Path

    The last panel of the day (I missed a good part of one in between, unfortunately) is on the FDA’s Critical Path initiative and personalized medicine in general. It’s moderated by Greg Simon of FasterCures, and features Michelle Hoffman of Drug Discovery and Development, Robert McBurney of BG Medicine, Gualberto Ruaño of Genomas, John S… Read More
  • Press Coverage

    CMPI Conference: CATIE and ALLHAT

    The third conference is on the CATIE and ALLHAT trials, the large comparative studies of antipsychotic and hypertensive medications. These studies are taking a real beating, I have to say. Herbert Meltzer of Vanderbilt took on the CATIE work, saying that its design was too complex and tried to do too many things at once. Read More
  • Cardiovascular Disease

    It Should Work. It Just Doesn’t.

    The late-stage clinical failure of a small company/big company drug partnership story gets told over and over, and today it was the turn of Renovis and AstraZeneca. Renovis had come up with a candidate (NXY-059) for post-stroke therapy that targeted free-radical oxidative damage. Initial clinical trials were fairly positive, but this latest one, a… Read More
  • The Central Nervous System

    Touch Me Not

    I see that Dylan found an old bottle of L-DOPA in his stockroom – I’d handle that one with gloves, but that’s the medicinal chemist in me talking. He segues into a discussion of the MPTP story, which I talked about here a while back. Every med-chemist who’s done work on central nervous system drugs… Read More
  • Business and Markets

    Neurocrine’s Choice

    It’s been an awful time to hold the stock of a small company called Neurocrine. They’ve been developing an insomnia therapy (Indiplon), and things seemed to be going along reasonably well. It’s a crowded field. The compound is in the same GABA mechanistic class as the existing drug Ambien (which makes it in the same… Read More