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Posts tagged with "The Central Nervous System"

  • Biological News

    Those Compounds Aren’t What You Think They Are

    There’s a lot of work in the literature on the TrkB receptor, which responds to brain-derived neutrotrophic factor (BDNF). That name certainly makes the ligand protein sound like a pretty big deal, and so it is: BDNF is involved in a lot of neural development pathways, injuries to nerve tissue, and the like, and given… Read More
  • Clinical Trials

    Ultrasound For Brain Drug Delivery – Not So Fast

    I wrote a couple of years ago here about the idea of making the blood-brain barrier more permeable by the use of focused ultrasound, in the presence of injected microbubbles. This would be a very useful thing if it works – as anyone who’s been concerned with central nervous system drugs (or drug delivery in… Read More
  • Clinical Trials

    A New Parkinson’s Therapy – Possibly

    There’s a new report of progress in Parkinson’s disease, and from an unexpected direction. Well, it was unexpected for me, anyway. Parkinson’s is, famously, a condition that is driven by the steady deterioration of dopamine-rich neurons in the brain, most particularly in the substantia nigra region. An impressive amount of researc… Read More
  • Biological News

    Parkinson’s As An Autoimmune Disease: More Evidence

    For many complex diseases, you’ll find that there are a couple of hypotheses floating around them that are hard to prove and hard to disprove: one is that they’re actually caused by some (as yet unrecognized) infectious agent, and the other is that that they’re actually an autoimmune/inflammatory disorder. You can also recognize t… Read More
  • Drug Industry History

    Effective CNS Drugs Are Where You Find Them

    Here’s an interesting post over at Slate Star Codex (a site that generates a lot of them), on psychiatric drugs. The question is, what are the most interesting and potentially useful developments in this area over the last ten or twenty years? And the answer might well be things based on drugs of abuse: The… Read More
  • The Central Nervous System

    The End of the Serotonin Transporter Gene Story?

    For over twenty years, there’s been interest in the idea that changes in the serotonin transporter protein might be associated with depression in humans. The hypothesis makes some sense on the face of it, although the entire serotonin/depression connection is a lot more complicated than it’s thought to be in the popular imagination. The… Read More
  • Biological News

    Hope For Nonaddictive Opioid Painkillers

    No one needs to be told about the opioid painkiller problem in this country. There are legal, commerical, regulatory, and ethical ways to look at it, but from a pharmacological standpoint, the whole thing would be a lot easier to deal with if there were any highly effective non-addictive painkillers. But that’s exactly what we… Read More
  • How Not to Do It

    How Not to Do It: Dosing Volunteers

    Well, here I post about the ethical problems of using normal volunteers in Phase I studies, and this story comes along. It’s not exactly an investigational drug trial – two students (in “Sports Science”) at Northumbria University in England were being given caffeine to measure its effects on exercise. But there was a bit of… Read More
  • Alzheimer's Disease

    Clinical Trials, Up and Very Much Down

    Lots of news at both ends of the scale today. At the bad end would be Arrowhead Pharma, who have been exploring therapeutic RNA interference. That’s a hard row to hoe, and nothing illustrates that better than their announcement that they’re dropping three clinical programs, pretty much all the advanced research that they have, because… Read More
  • Clinical Trials

    A Quiet And Sudden Exit for Amiselimod

    Here’s an example of a common behavior in this industry – and to be fair, in many others as well. Big deals are celebrated and press-released at the outset, but if things don’t work out, they end very quietly – as quietly as possible. Sometimes that’s not very possible at all, because a big Phase… Read More
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