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  • Blasting Your Way In

    Getting drugs of any sort through the blood-brain barrier is never something that can be taken for granted, and if your therapeutic agents is well outside the u… Read More
  • Prions In the News (Unfortunately)

    Let’s talk about proteins for a few minutes – nasty, unfriendly proteins, of the sort that will ball up and crash out of solution the first chance t… Read More
  • Loosening Things Up in Japan

    Japan is going to try opening up its medical approval process for regenerative medicine (no doubt with an eye on its aging population). Regulatory changes that… Read More
  • Invisible Crystals Yield Structure

    A crystallographer colleague passes on this new paper, which I find very interesting and just a bit freaky. The authors (a collaboration between UCLA, HHMI, LBN… Read More
  • Target Invalidation

    Target validation is a key process in drug discovery, naturally. But it’s worth remembering that target invalidation happens more often, and is also impor… Read More
  • Bromodomain Ligands and Memory

    Epigenetics has been a hot field the last few years (although not quite hot enough for Roche to buy out their partners in the area, Constellation). One of the t… Read More
  • A 3D Printed Drug?

    Several readers have sent along news of what’s billed as the “world’s first 3D-printed drug”. That got my attention, because there have… Read More
  • Sertraline in the Courts

    Potential trouble: thoughts of a link between cardiac birth defects and the antidepressant Zoloft (sertraline). Pfizer recently won such a case in Missouri, but… Read More
  • Four Patients. Count ‘Em, Four.

    While we’re on the subject of market froth, take a look at what’s going on today. Sage Therapeutics announced the results of a study in post-partum… Read More
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