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Posts tagged with "The Central Nervous System"

  • The Central Nervous System

    The Brain Is Actually Connected to the Lymphatic System

    Here’s a surprise: there are lymphatic vessels going into the brain. That’s reported in this paper in Nature. (Here’s a pretty breathless press release from the University of Virginia, where the work was done). I’m no immunologist, but the work (done mostly in mice, and extended to human samples) looks pretty solid to me. We… Read More
  • Business and Markets

    Some Side Effect For An Antibody

    Remember back when AstraZeneca was fighting off Pfizer’s ardent, tax-issue-resolving embrace a year ago? One of their weapons was a pitch to their own shareholders about what potential their own pipeline had, and how much of that would presumably go to waste should the deal go through. Even at the time, people thought that their… Read More
  • Drug Assays

    More on TC-2153

    Yesterday’s post on TC-2153 and its assay activity brought a note from Paul Lombroso at Yale, whose group is doing this work. With his permission, here’s an update (slightly edited): We have now used the drug orally in nonhuman primates with cognitive deficits: it had significant results. . .we have also given it to both… Read More
  • Alzheimer's Disease

    Sulfur, Sulfur, Sulfur

    Does anyone know of any phosphatase inhibitors that aren’t hideous? I ask this because someone sent along a question about this paper, from last August, that I’d missed at the time (press release here, but the paper’s open-access as well). Here’s a commentary in the journal itself. It’s work from Yale on an enzyme call… Read More
  • Clinical Trials

    Genervon and ALS: What’s Going On Here?

    Ever hear of Genervon, and their ALS therapy, GM604? There’s not too much to hear about, unless of course you’re a desperate patient or relative, looking for something, anything that might help. Genervon is certainly trying to reach those people, with press releases that include phrases such as “dramatic” and “very rob… Read More
  • Clinical Trials

    Finding Placebo Responders

    We all know about the placebo effect – in some therapeutic areas (depression being a classic case), it’s so strong that finding a drug that works better is no small feat. And it’s been thought for some time that the strength of the placebo response varies from patient to patient, in ways that aren’t really… Read More
  • The Central Nervous System

    Hallucinogenic Therapy

    Too bad Alex Shulgin didn’t live to see this article in the New Yorker. It’s on the reviving field of psychiatric treatment using psychedelic drugs. This was an active area in the 1950s and 1960s, as many people know, although some of what people think they know about that era is not true. But it’s… Read More
  • The Central Nervous System

    Expensive Placebos Work Better

    The placebo effect weirds everyone out. I think we can say that without much fear of contradiction. It seems like magic, the fact that just thinking that you’re getting some treatment of benefit can have actual benefits. Magic, though, it is not. This new study in the journal Neurology (press release here) is, at first… Read More
  • Chemical News

    More Designer Drugs

    Here’s a good article on the illegal recreational drug trade – the boutique end of it, anyway. I’ve written about this sort of thing before, and this piece is squarely in the same territory (even to interviewing David Nichols). It all comes down to this: there are quite a few people out there modifying known… Read More
  • General Scientific News

    The Broad Gets $650 Million For Psychiatric Research

    The Broad Institute seems to have gone through a bit of rough funding patch some months ago, but things are looking up: they’ve received a gift of $650 million to do basic research in psychiatric disorders. Believe it, that’ll keep everyone busy, for sure. I enjoyed Eric Lander’s characterization of much of the 1990s work… Read More