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Posts tagged with "The Scientific Literature"

  • Chemical News

    Quis Custodiet Ipso Custodes?

    Yesterday’s look into the Google Ngram data set brought up a discussion in the comments on how good the numbers are in it (and in other large datasets). “Garbage in, garbage out” is as true a statement as ever, so it’s a real worry. (Even if the data were perfect, the numbers could still be… Read More
  • General Scientific News

    A Google Oddity

    A comment to the last post mentioned that if you search the word “biotechnology” in Google’s Ngram search engine, something odd happens. There’s the expected rise in the 1970s and 80s, but there’s also a bump in the early 1900s, for no apparent reason. Curious about this, I ran several other high-tech phrases through a… Read More
  • Drug Industry History

    Ups and Downs

    I was thinking the other day that I never remembered hearing the phrase “Big Pharma” when I first got a job in this business (1989). Now I have some empirical proof, thanks to the Google Labs Ngram Viewer, that the phrase has only come into prominence more recently. (Fair warning: you can waste substantial amounts… Read More
  • Chemical News

    What Medicinal Chemists Really Make

    Chemists who don’t (or don’t yet) work in drug discovery often wonder just what sort of chemistry we do over here. There are a lot of jokes about methyl-ethyl-butyl-futile, which have a bit of an edge to them for people just coming out of a big-deal total synthesis group in academia. They wonder if they’re… Read More
  • The Scientific Literature

    The Top 100 Chemists?

    I’m never sure of how useful these rankings are, but here’s Thomson Reuters’ rankings of the top 100 chemists of the last ten years. This is based on publications and their impact/citation rate. Looking over the list, I think that there are some artifacts in it, and boy, don’t metal-organic frameworks and nanotech just rate… Read More
  • The Scientific Literature

    Great Moments in Journal Editing

    I don’t know if this DOI link resolves yet – or if the problem will be fixed by the time it does. But for now, in the “Articles in Press” queue over at Drug Discovery Today, they have one whose title reads like this: Utility of protein structures in overcoming ADMET-related issues of drug-like compounds[1. Read More
  • The Scientific Literature

    Keep On Scrollin’

    I’ve been browsing through my journal RSS feeds, and a question occurs to me. When you’re scanning through the current literature, what sort of paper makes you most likely to keep scrolling? What kind of work are you least likely to actually read? We’ll stipulate that you’re looking at a journal or subject that’s relev… Read More
  • The Scientific Literature

    Just A Few More Month’s Work, That’s All I’m Asking Here

    Here’s the cry of someone who’s been jerked around by too many journal referee reports. Hidde Ploegh of the Whitehead Institute has a piece in Nature News called “End the Wasteful Tyranny of Reviewer Experiments”. That could have just possibly have been phrased more diplomatically, but I know what he’s talking about. T… Read More
  • The Scientific Literature

    Graphical Crankiness

    And now a brief note from the “trivial but annoying” department, since it’s been a couple of years since I last complained about this. Is there any way that we can start a petition, or take up a collection, or do something to make K. C. Nicolaou stop drawing ring systems like this? Coloring the… Read More
  • The Scientific Literature

    So Much For Natural-Product Nevirapine

    Remember that weird Tetrahedron paper from last December? The one that claimed that it isolated the reverse transcriptase inhibitor nevirapine as a natural product from an Indian plant? In chiral form, no less? Well, the journal would now like to say “Never mind“. The lead author has retracted the paper, “due to doubt created in… Read More
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