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Posts tagged with "Toxicology"

  • Business and Markets

    The Supreme Court Slams Big Pharma? Not Exactly.

    The Supreme Court came down with a decision the other day (Matrixx Initiatives v. Siracusano) that the headlines say will have an impact on the drug industry. Looking at it, though, I don’t see how anything’s changed. The silly-named Matrixx is the company that made Zicam, the zinc-based over-the-counter cold remedy that was such a… Read More
  • Current Events

    Potassium Iodide Pills

    Well, the nuclear crisis in Japan seems to be causing a run on potassium iodide (KI), and not just in Japan. If news reports are to be believed, people in many other regions (such as the west coast of the US and Canada) are stocking up, and some of these people may have already started… Read More
  • The Dark Side

    Thallium Poisoning? In This Day and Age?

    Thallium poisoning? Now someone in the lab has really lost it. But that seems to be what happened in New Jersey, with a chemist from Bristol-Myers Squibb accused of doing in her husband. A note to the Newark Star-Ledger and some other newspapers: even though a hot isotope of it is occasionally used in medicine… Read More
  • Drug Development

    Oh, And While You’re At It. . .

    Well, this is a question that (I must admit) had not crossed my mind. Courtesy of Slate, though, we can now ask how we can make pharmaceuticals more environmentally friendly. No, not the manufacturing processes: this article’s worried about the drugs that are excreted into the water supply. It’s worth keeping an eye on this… Read More
  • The Central Nervous System

    More On Homemade Street Drugs

    I wrote here about a Wall Street Journal article covering illegal street-drug labs in Europe. Well, maybe that should be not-quite-illegal, because the people involved were deliberately making compounds that the law hadn’t caught up with yet. The article mentioned David Nichols at Purdue as someone whose published work on CNS compounds had be… Read More
  • Cardiovascular Disease

    Merck’s CETP Compound: Still Alive, But The Big Fun Awaits

    Four years after the torcetrapib disaster, Merck has released some new clinical trial data on their own CETP inhibitor, anacetrapib. It’s doing what it’s supposed to, when added to a statin regimen: decrease LDL even more, and strongly raise HDL. So that’s good news. . .but it would actually be quite surprising if these numbers… Read More
  • Clinical Trials

    Vivus, Qnexa, Arena, Lorcaserin and the FDA

    One big story from the last week was the FDA advisory panel’s “No” decision on Qnexa, the drug-combo obesity therapy developed by Vivus. This is the one that’s a combination of phentermine and topiramate, both of which have been around for a long time. And clinical trials showed that patients could indeed lose weight on… Read More
  • Cardiovascular Disease

    Avandia: Was the Evidence Buried?

    The New York Times has added to the arguments over Avandia (rosiglitazone) this morning, with an above-the-fold front page item on when its cardiovascular risks were first discovered. According to leaked documents, that may have been as early as the end of 1999 – just a few months after the drug had been approved by… Read More
  • Drug Assays

    Natural Products: Not the Best Fit for Drugs?

    Stuart Schreiber and Paul Clemons of the Broad Institute have a provocative paper out in JACS on natural products and their use in drug discovery. As many know, a good part of the current pharmacopeia is derived from natural product lead structures, and in many other cases a natural product was essential for identifying a… Read More
  • Cardiovascular Disease

    Steve Nissen vs. GlaxoSmithKline

    You don’t often get to see so direct an exchange of blows as this: Steve Nissen, of cardiology and drug-safety fame, published an editorial about GlaxoSmithKline and Avandia (rosiglitazone) earlier this year in the European Heart Journal. And GSK took exception to it – enough so that that the company’s head of R&D, Moncef Sla… Read More
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