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Posts tagged with "Toxicology"

  • Drug Assays

    We Can’t Calculate Our Way Out of This One

    Clinical trial failure rates are killing us in this industry. I don’t think there’s much disagreement on that – between the drugs that just didn’t work (wrong target, wrong idea) and the ones that turn out to have unexpected safety problems, we incinerate a lot of money. An earlier, cheaper read on either of those… Read More
  • Drug Development

    A Question: Monoclonal Antibodies in the Clinic

    A reader sends along this query, and since I’ve never worked around monoclonal antibodies, I thought I’d ask the crowd: how much of a read on safety do you get with a mAb in Phase I? How much Phase I work would one feel necessary to feel safe going on to Phase II, from a… Read More
  • Drug Development

    Why Not Bromine?

    So here’s a question for the medicinal chemists: how come we don’t like bromoaromatics so much? I know I don’t, but I have trouble putting my finger on just why. I know that there’s a ligand efficiency argument to be made against them – all that weight, for one atom – but there are times… Read More
  • Analytical Chemistry

    Thalidomide, Bound to Its Target

    There’s a new report in the literature on the mechanism of thalidomide, so I thought I’d spend some time talking about the compound. Just mentioning the name to anyone familiar with its history is enough to bring on a shiver. The compound, administered as a sedative/morning sickness remedy to pregnant women in the 1950s and… Read More
  • General Scientific News

    All Natural And Chemical Free

    Yesterday’s link to the comprehensive list of chemical-free products led to some smiles, but also to some accusations of preaching to the choir, both on my part and on the part of the paper’s authors. A manuscript mentioned in the blog section of Nature Chemistry is certainly going to be noticed mostly by chemists, naturally… Read More
  • Clinical Trials

    The Virtual Clinical Trial: Not Quite Around the Corner

    Here’s one of those “Drug Discovery of. . .the. . .Future-ure-ure-ure” articles in the popular press. (I need a reverb chamber to make that work property). At The Atlantic, they’re talking with “medical futurists” and coming up with this: The idea is to combine big data and computer simulations—the kind an engi… Read More
  • Chemical News

    Whack-A-Mole

    I noticed some links to this post showing up on my Twitter feed over the weekend, and I wanted to be sure to mention it. There’s a recipe for “all-natural” herbicide that goes around Facebook, etc., where you mix salt, vinegar, and bit of soap, so Andrew Kniss sits down and does some basic toxicology… Read More
  • Drug Assays

    A New Way to Study Hepatotoxicity

    Every medicinal chemist fears and respects the liver. That’s where our drugs go to die, or at least to be severely tested by that organ’s array of powerful metabolizing enzymes. Getting a read on a drug candidate’s hepatic stability is a crucial part of drug development, but there’s an ever bigger prize out there: predicting… Read More
  • The Scientific Literature

    Pesticide Toxicity?

    There’s been a report on the toxicity of various pesticides in the literature suggesting that they’re far more toxic to human cells than had been thought. My eyebrows went up a bit when I heard this, because these sorts of assays had been done many times before. Then I realized that this was another paper… Read More
  • Chemical News

    The West Virginia Formaldehyde Claim Is Nonsense

    This morning I heard reports of formaldehyde being found in Charleston, West Virginia water samples as a result of the recent chemical spill there. My first thought, as a chemist, was “You know, that doesn’t make any sense”. A closer look confirmed that view, and led me to even more dubious things about this news… Read More
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