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Posts tagged with "Uncategorized"

  • Chemical Biology

    More Spring-Loaded Reagents

    I wrote just about this time last year about a new “strain-release” bond forming reaction system from the Baran group at Scripps. Now they’ve got a good-sized paper in JACS with more reactions in that line, but be warned. If you hit “Print” on the Supporting Information file, you’d better have spare paper, becaus… Read More
  • In Silico

    The Flightosome

    I got this diagram from Arjun Raj‘s Twitter feed, and I think I enjoy it a bit more every time I see it. Some of that is because it’s a big part of what I was trying to get across in this column, but I think that the sketch does a more thorough job of… Read More
  • Chemical Biology

    Curcumin Will Waste Your Time

    I really enjoyed reading this article in J. Med. Chem. on curcumin. (Update: here’s the take over at Practical Fragments). That’s a well-known natural product, found in large quantities in turmeric root (which is where most of the yellow color comes from). It has, over the years, been a hit in many, many assays, and… Read More
  • In Silico

    Watson and Pfizer

    I have wondered several times around here about how (and if) IBM’s Watson platform is going to be able to help out with drug discovery, and it looks like we may be able to find that out. Pfizer has signed up with IBM to use the Watson technology in its immuno-oncology research. Here we go: Watson… Read More
  • Chemical News

    Nitration Isn’t So Simple

    OK, let’s get physical organic here for a little while. For atat ose outside the field, physical organic chemistry is the branch that studies how and why the reactions of organic chemistry happen – the details of which bonds break and form, in what order, in what arrangement, where the atoms and electrons are moving and… Read More
  • Chemical News

    Calculating A Few Too Many New Compounds

    The phrase “automatic chemical design” will generally get my attention, especially when it’s applied to drug-like molecules. And that’s one the the key parts of this paper, from researchers at Harvard, Toronto, and Cambridge. From what I can see, they’re trying to come up with a new technique for generating potential n… Read More
  • Pfizer Bails on PCSK9 antibodies

    Well, no sooner do I mention that Pfizer has a PCSK9 antibody coming along in the clinic then they don’t. Not any more. The company has announced that they’re discontinuing bococizumab, which comes as a surprise to most everyone, since they’d been spending substantial time and money on it. The company has concluded that it’s… Read More
  • Inside Theranos: Yikes

    I always wondered what sort of place Theranos must be (have been) to work at, and now this piece at Vanity Fair answers the question: hellish. The treatment of chief scientist Ian Gibbons, as presented in the article, will illustrate the point: Gibbons, who was diagnosed with cancer shortly after joining the company, encountered a… Read More
  • Chemical News

    The New Age of Organic Synthesis

    Earlier this year I wrote about a couple of new coupling methods that use carboxylic acids to alkylate aryl groups. Now there’s another winner to report: the MacMillan group is out with a nickel-catalyzed reaction that does something similar, only it forms aliphatic C-C bonds. This is the sort of reaction that people have been… Read More
  • Chemical News

    Rip Up Your Prolines

    Here’s an interesting paper in the “modify at the last step” genre from Christina White’s group at Illinois (press release here). They’ve been investigating oxidative C-H functionalization by iron species (which takes me back to the days when I used to attend Sir Derek Barton’s consulting sessions at my first job… Read More