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Posts tagged with "Uncategorized"

  • Life in the Drug Labs

    No Water, No Problem

    I have some colleagues who are evaluating these “no flowing water” condensers for reactions. Anyone out there have any experience with them? It’s for sure that there have been a lot of lab floods over the years from condenser hoses that pop off, and the expense of all that water can be a problem, too. Read More
  • Analytical Chemistry

    Asphalt, Up Close and Personal

    I wrote not long ago about another use of atomic force microscopy images to determine chemical structures, and now here’s another paper on the same general topic. Pretty soon, this is going to become too common to note, and structure determination will have changed forever (once again!) Shown are some asphaltenes – and if you’ve… Read More
  • Business and Markets

    What Became of Cubist

    Cubist was one of the pure-play antibiotic companies, until Merck bought them in late 2014. And once they’d done that, they wasted no time at all making their rationale clear. They wanted Cubist’s late-stage clinical assets, and they had no use whatsoever for Cubist’s R&D people, whom they quickly fired en masse. Treating the… Read More
  • The Least Useful Element For Organic Chemistry?

    I’ve recently been adding to my list of elements I’ve worked with, which is a nice effect of my current side project. I’ll do an updated post once I total things up; there are some more on order, but I can tell you that I’ve already checked off a number of the ones mentioned in… Read More
  • Chemical News

    Asking the Employees

    Every company that I’ve ever worked for has said that they want suggestions from the employees – some of them have been serious, and others were saying it because that’s the sort of thing you’re supposed to say. There are, naturally, all sorts of levels to consider. Some suggestions are small and easily implemented (or… Read More
  • Science Gifts 2014: Experiments at Home

    This is a repost of a “Science Gifts” suggestion from last year – from what I can see, the field hasn’t had any major additions in the past few months, and the recommendations below are all still relevant. Interesting science-gift ideas can be found in the “home experiments” area. There’s been a small boom… Read More
  • EMBL Chemical Biology: Polypharmacology

    Brian Shoichet is talking about the old days, 1930 to about 1985 or so. He mentions that Sir James Black called it “rational drug design” back then, which must have been a reaction to something that was considered really irrational. But these guys had a lot of advantages, which is what’s leading people back to… Read More
  • EMBL Chemical Biology: Substrate Activity Screening

    The day starts off with Jonathan Ellman talking about substrate activity screening, a very interesting technique that builds on optimized artificial enzyme substrates and turns them into inhibitors. He’s published a number of papers on this, and it looks like his current efforts are targeting phosphatases. I wish him luck with that; those hav… Read More
  • Bosutinib: Don’t Believe the Label!

    Now here’s a worrisome thought, if you’re doing kinase research. A tyrosine kinase inhibitor in the clinic against Bcr-Abl, bosutinib (SKI-606), is also being used as a research tool in a number of academic groups. But they’re probably not using what they think they’re using. This article has the details. The compound has a… Read More
  • The Academic-Industrial Collaboration in Drug Discovery Panel: Today

    As mentioned before, I’m going to be moderating a panel today on industry-academic collaborations in drug discovery at the SLAS meeting in San Diego. It starts at 10:30 AM Pacific Time, and you can access a live stream of the event here (scroll down). And if anyone has more questions on the subject they’d like… Read More