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Posts tagged with "Uncategorized"

  • Analytical Chemistry

    PAINs by X-Ray

    It’s safe to say that the concept of “pan-assay interference compounds” evokes some strong feelings in medicinal chemists. And those feelings run in several directions: some people are very glad to have a tool with which to winnow down their screening hit lists (or at least to prioritize them), while others are infuriated by the… Read More
  • Press Coverage

    Where Does the News Hype Come From?

    From Chris Chambers on Twitter (of Cardiff Univ.) come some very important points about press coverage of scientific results. I often make references here to misleading and inaccurate headlines and stories in the popular press – as a scientist, it’s hard to take, seeing research results mangled in the only venues that most people will… Read More
  • Analytical Chemistry

    Tickling Individual Bonds

    When you get down to it, most of the ways that we chemists have to make our reactions work are not very elegant. We can change solvents, mess with ligands, drip A into B slowly instead of B into A, etc. But we’re still depending on the molecules involved just running into each other. We… Read More
  • Chemical News

    Down At the Small Surfaces

    Mechanochemistry – getting chemical reactions to occur by pressing, pulling, and grinding solid substances – continues to produce weird and interesting results. Here are a couple of recent ones from the same issue of Angewandte Chemie, both from a group at McGill. This paper is about making soluble compounds of the noble metals (such a… Read More
  • Biological News

    The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Munich) characterize 243 (!) kinase inhibitors that have made it into human trials across a very wide range of the known kinase enzymes, and the result is… Read More
  • Biological News

    Mistreating Enzymes For a Good Cause

    What happens when you chuck an active enzyme into the wrong solvent? Well, it stops working (or at the very least, it stops working as well as it did). And how do you know which one is the wrong solvent? Why, those are the ones that make it stop working. That round trip is to… Read More
  • In Silico

    Objections to (Some) Drug Discovery AI

    Here’s a piece to start some arguing: “AI in Drug Discovery is Overhyped”, by Mostapha Benhenda. I realize that a lot of people will read that title and go “Well, yeah, sure”, but it’s definitely worth seeing some specific examples (which the post has). Update: some of the authors involved have left detailed comm… Read More
  • Business and Markets

  • Chemical Biology

    Catching Up With Protein Degradation

    Just a short note today – I know that a lot of readers in the Northeast will be snowed out of work today anyway, but there are plenty of others who aren’t! I wanted to mention this short review on targeted protein degradation in J. Med. Chem. (a subject I last wrote about here). It’s… Read More
  • Alzheimer's Disease

    Alzheimer’s and the Rare Disease Model

    Politico is a good source for national political stories, but I don’t usually look to them for coverage of drug development. But they’ve done a good job with their recent “Pharma Issue”. One of the stories (by David Freedman) is on the difficulties of Alzheimer’s drug discovery, which are legendary. The contrast betwe… Read More
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