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Posts tagged with "Uncategorized"

  • Cancer

    Bacteria and Cancer: Another Connection

    Three months ago, I wrote about a report that some kinds of pancreatic cancer seem to be associated with particular infections, and wondered “How many similar stories are out there that we don’t know about yet?” Well, that didn’t take long to start being answered. This recent paper in Science (from a multicenter team: Dana- Read More
  • Biological News

    Genetic Variation Gets More Real All the Time

    This study goes firmly into the file marked “You never could have done this one a few years ago, sonny”. We already know that there’s genetic variation in every population and in every individual. And we know that a large number of marketed drugs (about a third of them) target G-protein coupled receptors (GPCRs). But… Read More
  • Chemical News

    Hydrothermal Vents Weren’t Home?

    It’s probably not surprising, but you would be hard pressed to find an area that’s full of more intractable arguments than origin-of-life studies. There are so many theories, because it’s relatively easy to add new ones, and it’s difficult to impossible to put many of them to the real test. Meanwhile, the scientific stakes a… Read More
  • Business and Markets

    ‘Tis Unfortunately the Season

    Update: this post came just a few days before Teva announced that they’re starting a 14,000-job cutback, to run over the next two years. The season indeed. Unfortunately, the Thanksgiving-to-Christmas season is a traditional one in the drug industry for layoffs and site closures. This is especially true for larger companies, who time these th… Read More
  • Book Recommendations

    Medicinal Chemistry Books 2017

    I’m running a few days later than usual, but here’s this year’s list of medicinal chemistry books of interest. As in years past, the list builds on previous recommendations, with updates and reader suggestions incorporated along the way. For histories and broad overviews of the field, it doesn’t appear that any new titles m… Read More
  • Analytical Chemistry

    How a Compound Dissolves – One Water Molecule At a Time

    Here’s another one of those nanoscale articles that gives me a bit of a shiver, because it shows pictures of something that I had assumed was beyond our ability to see. The authors, from the Ruhr University in Bochum, are looking at a simple organic molecule (an azobenzene, shown at right), adsorbed onto a solid… Read More
  • Analytical Chemistry

    Two Molecules, When You Were Expecting Just One

    Here’s a good short review on a subject that doesn’t come up too often in drug discovery, but can be a major headache when it does: atropisomerism. There are all sorts of structural isomers possible for organic compounds, and students in their second-year class have a joyful time learning them and keeping them straight. But… Read More
  • Drug Assays

    New Antibiotic Action

    I’m always happy to hear about new agents to treat gram-negative bacterial infections, especially after a stint working in antibiotic drug discovery myself. Seeing just how hard it is to kill these things did not improve my peace of mind about the problem of bacterial resistance, that’s for sure. So this paper caught my eye… Read More
  • Current Events

    Taxing Graduate Students

    Today’s blog post will be of interest mostly to US readers, since it concerns the US tax code. There has, of course, been a huge push recently for an overhaul of the tax system, with bills passing both the House and Senate. I am not, absolutely not, going to get into the details of either… Read More
  • Chemical News

    Sixty-Three Years in Chemistry: An Interview with Donald Batesky

    So I wrote here about Donald Batesky, the 85-year-old synthetic organic chemist at the University of Rochester who recently published a paper in the Journal of Organic Chemistry. He contacted me afterwards, and I ended up talking to him for quite a while about his career, which has been long (clearly!) and varied. With his permission… Read More
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