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Posts tagged with "Uncategorized"

  • Analytical Chemistry

    Two Molecules, When You Were Expecting Just One

    Here’s a good short review on a subject that doesn’t come up too often in drug discovery, but can be a major headache when it does: atropisomerism. There are all sorts of structural isomers possible for organic compounds, and students in their second-year class have a joyful time learning them and keeping them straight. But… Read More
  • Drug Assays

    New Antibiotic Action

    I’m always happy to hear about new agents to treat gram-negative bacterial infections, especially after a stint working in antibiotic drug discovery myself. Seeing just how hard it is to kill these things did not improve my peace of mind about the problem of bacterial resistance, that’s for sure. So this paper caught my eye… Read More
  • Current Events

    Taxing Graduate Students

    Today’s blog post will be of interest mostly to US readers, since it concerns the US tax code. There has, of course, been a huge push recently for an overhaul of the tax system, with bills passing both the House and Senate. I am not, absolutely not, going to get into the details of either… Read More
  • Chemical News

    Sixty-Three Years in Chemistry: An Interview with Donald Batesky

    So I wrote here about Donald Batesky, the 85-year-old synthetic organic chemist at the University of Rochester who recently published a paper in the Journal of Organic Chemistry. He contacted me afterwards, and I ended up talking to him for quite a while about his career, which has been long (clearly!) and varied. With his permission… Read More
  • Drug Industry History

    Reading the Minds of Medicinal Chemists

    I suppose that all of us medicinal chemists should be flattered by this press release. According to it: Medicinal chemistry is among one of the most important and intellectually-challenging professions on the planet. It takes decades of training and experience to learn the properties of the thousands of molecules and their effects on the biological… Read More
  • Animal Testing

    Melanocortin: It’s Not Just For Lizards Any More

    If you’re looking for a good example of evolution-as-a-tinkerer, the melanocortin receptors would be a good place to start. From a single starting point, they’ve ended up as a family of related proteins that do completely different things. And the hormones that bind to them have radiated out as well: they’re all derived by process… Read More
  • Business and Markets

    A Grim Future? Here Are the Numbers.

    Here’s a bracing look at the state of the pharma business, especially regarding R&D costs and return on investment. And let me warn you – it’s not a feel-good sort of article, but the figures are hard to refute. The author, Kelvin Stott, comes out swinging: Here I apply a far simpler, much more robust… Read More
  • Analytical Chemistry

    Stereochemical Mysteries, Solved

    Ask a chemist (I’ll do) about optical rotation, and you’ll get a confident answer about how right- and left-handed isomers of chiral compounds will rotate polarized light that shines through a solution of one of them. Ask one of us exactly how it does that, and in 99 cases out of a hundred, you’ll witness… Read More
  • Chemical Biology

    HAT Inhibitors: Interpret With Care

    There are quite a few histone deacetylase inhibitors out there, from research tools to FDA-approved drugs. Those inhibit the enzymes that remove the acetyl epigenetic markers from histone proteins – but what about inhibitors of the enzymes that put them on? Those are histone acetyltransferases (HATs), and they’ve naturally been the subj… Read More
  • The Scientific Literature

    An Odd Paper?

    Nanoparticles came up around here the other day, and now a reader sends along a new paper in the field that’s. . .a bit odd. Maybe more than a bit. It’s been accepted at ACS Applied Materials and Interfaces, and you have to wonder what the referee reports were like. It’s titled “Earthicle: The Design… Read More
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