• August 16, 2002

    Here It Goes

    The research idea I’ve been alluding to recently gets a key test today. I’ve got two values for one of the variables (high and low, essentially) and four values for another. And I’ve thought up two control experiments for each of those eight cases, which narrows things down quite a bit: under this experimental protocol… Read More
  • Nature Stood Me Up

    . . .not for the first time either, and doubtless not for the last. For anyone stopping by to get an update on my experiment, well, not very much happened. The controls all worked about like I figured they would, but the real experimental cases refused to do anything. And the one run that perhaps… Read More
  • August 15, 2002

  • August 14, 2002

  • August 13, 2002

  • August 11, 2002

    Life of the Party

    My earlier gloss of the Journal of Medicinal Chemistry as “Jay Med Chem” prompts me to provide a complete guide to faking your way into sounding like a professional organic chemist. Not that that’s the road to fame and fortune, but you never know when it’ll come in handy. The first lesson is the lingo… Read More
  • August 8, 2002

    Better Them Than Me

    Roche and their partner, Trimeris are developing an anti-HIV compound (called T-20) that has some remarkable features. It’s the first to target a cell protein (gp-41) that is a key binding step in HIV’s mode of infection, for one thing. But to be more precise, it has 106 more interesting things about it – that’s… Read More
  • August 4, 2002

    Close to the Vest

    Another line in one of the aforementioned Paul Orwin posts rang true for me. He was discussing some new ideas in antibacterial research, then brought himself up short as he got close to his own work: “In the highly competitive world of academic science, even a weblog is no place to divulge current research tidbits” Read More
  • Close To the Vest

    Another line in one of the aforementioned Paul Orwin posts rang true for me. He was discussing some new ideas in antibacterial research, then brought himself up short as he got close to his own work: “In the highly competitive world of academic science, even a weblog is no place to divulge current research tidbits” Read More
  • August 1, 2002

    Breathing and Aging

    I’ve written about the idea that aging is related to oxidative damage (most recently on June 3.) There’s a lot of support for it, and the documented life-extending properties of caloric restriction are thought by many to be tied into this hypothesis. CR has worked in (for example) fruit flies and rodents, and some slow-moving… Read More
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