• January 6, 2003

    Compare and Contrast

    Dwight Meredith over at PLA pointed out to me that the UC-Davis study on the prevalence of autism in California is online. It hasn’t been published in a journal yet, and the JAMA paper I mentioned last week doesn’t reference it. But the editorial comment in the same issue does. As it should, since there’s… Read More
  • January 5, 2003

    Ratio Rationalizations

    We spend a lot of time in drug discovery thinking about ratios. As we accumulate data about our compounds, we start ranking them by how selective they are – “This one’s 10x versus the other receptor subtype and that one’s 50x,” you’ll hear someone say, or “We’ve got to get compounds at least 100-fold… Read More
  • January 2, 2003

    The Rate of Autism

    There’s a new study out in JAMA (free full text here) on the incidence of autism in the US population. Before getting to what the article actually says, it’s worth seeing what the media are saying it says. The New York Times headlines it “Study Shows Increase in Autism”, and Yahoo runs it as “Study… Read More
  • December 30, 2002

  • December 22, 2002

    Clearance Sale

    While I’m on the subject, I’ll mention some details that will be familiar to my fellow medicinal chemists. The body has a lot of mechanisms to deal with foreign substances. We assume that all our drugs are going to be handled by them, one way or another, and we just try to keep the stuff… Read More
  • Thimerosal – A Chemical Point

    I haven’t posted on this issue recently (although I’m working on a column for TechCentral Station,) but Dr. Manhattan has been writing some good pieces on it (check the comments sections for more.) There’s one thing I’d like to add, as an organic chemist. A persistant statement that I see about thimerosal is that it’s… Read More
  • Thimerosal – a Chemical Point

    I haven’t posted on this issue recently (although I’m working on a column for TechCentral Station,) but Dr. Manhattan has been writing some good pieces on it (check the comments sections for more.) There’s one thing I’d like to add, as an organic chemist. A persistant statement that I see about thimerosal is that it’s… Read More
  • Clearance Sale

    While I’m on the subject, I’ll mention some details that will be familiar to my fellow medicinal chemists. The body has a lot of mechanisms to deal with foreign substances. We assume that all our drugs are going to be handled by them, one way or another, and we just try to keep the stuff… Read More
  • December 20, 2002

  • December 18, 2002

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