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  • Who Discovers and Why

    The Root of All Results?

    Mentioning well-heeled research establishments that don’t produce results brings up an interesting question: is there a negative correlation between funding and productivity? You might think so, given the example cited in the previous post, and given the cases cited in Robert S. Root-Bernstein’s Discovering. There have been many great s… Read More
  • Academia (vs. Industry)

    Differences Between Industry and Academia, Pt. 1

    A reader’s e-mail got me thinking about this topic. It’s worth a number of posts, as you’d guess, since there are many substantial differences. Some are merely of degree (funding!), while others are of kind. But the funding makes for larger changes than you’d think, so I’ll get that one out of the way first. Read More
  • Drug Assays

    Our Cheerful Buddy, The Cell Membrane

    I sent off a manuscript to a chemical journal not long ago. There’s an initial flurry of e-mail activity when you do that – we’ve received your manuscript, we’ve sent your manuscript out to reviewers – and then a more or less prolonged period of silence. The next thing you hear is whether the paper’s… Read More
  • Business and Markets

    Pravachol vs. Lipitor Update

    In my March 11 piece below, I mentioned the possibility of Pravachol competing on price with Lipitor. But over at Forbes, Matthew Herper has pointed out that it’s currently more expensive. What BMS is going to do with this drug, I can’t imagine. There’s also a good story in the Newark Star-Ledger about the whole… Read More
  • The Scientific Literature

    The Universe, Which Others Call the Library. . .

    Want to feel old? Then let it hit you that there are entire scientific journals you used to read that don’t exist any more. I was looking up an old paper the other day in a German chemical journal, when it struck me that there aren’t as many of those as there used to be. Read More
  • Birth of an Idea

    Mismatched Socks

    Some miscellaneous updates tonight, in addition to the note appended to the post below. It seems that Sunday nights don’t often leave with time for more extensive blogging, and the world events of the last few days have made their claim on my attention as well. This isn’t going to be one of those dull… Read More
  • Business and Markets

    Ignorance Was Bliss

    Just a brief note today about the “PROVE-IT” study that Bristol-Meyers Squibb ran and has now reported on. This was their big shot at Pfizer’s Lipitor, their chance to show that their own statin, Pravachor, was just as good or better. The study was big, it was long, and man, was it expensive. It’s just… Read More
  • Autism

    A Mechanism for Thimerosal

    There’s some fresh news in the (quite possibly endless) debate about the vaccine preservative thimerosal. The Institute of Medicine is working on another report, due in several months. Their last report, in 2001, found no evidence to support a link, but didn’t dismiss the possibility, either. I’ve written about this topic before.… Read More
  • General Scientific News

    Nuclear Fusion, Wordsworth, German Cooking. The Usual.

    I’ve been remiss in not mentioning the new paper that’s coming out in Physical Review E from the group that’s reported possible sonochemical fusion. Their original paper from two years ago was the subject of one of my early blog posts (see the March 4 entry.) I’m very happy to hear that this work is… Read More
  • Infectious Diseases

    They Will Do Such Things. . .

    I see that Steven den Beste linked to me as a general source of med-chem info, which was good of him. He was discussing resistance in treatment of tuberculosis (on the way to a broader point about current events), so I thought I’d say a few words about antiinfective drugs. As I’ve mentioned in the… Read More