Honig has made important contributions to the development of tools for structural biology, though I know him -- though not very well -- as a computational biologist.
For me, the interesting part of the interview was the first, after Nybo asks, "In building your career, what was your most significant obstacle." His answer: He was so interdisciplinary that it was difficult for him to find a home.
Honig earned his Ph.D. in chemical physics, then switched to biology for his postdoc. "But when I finished my postdoc," he says, "I encountered a form of cultural bias that still exists to a lesser extent today: physicists and chemists viewed working in biology as a lower level activity while biologists, rightfully, said I wasn't a real biologist. Consequently, I couldn't find a job."
"Was I a chemist? A biologist? What department would I be comfortable in?," he asked himself. "It was a long struggle, and one I still see today with young people doing interdisciplinary research." Eventually he made his way to Columbia, where he found a very comfortable fit.