Oh, man. Here’s another example of an old, sad story – just a little fakery at the beginning, and here’s what it leads to:
Government prosecutors said (Dong-Pyou) Han’s misconduct dates to 2008 when he worked at Case Western Reserve University in Cleveland under professor Michael Cho, who was leading a team testing an experimental HIV vaccine on rabbits. Cho’s team began receiving NIH funding, and he soon reported the vaccine was causing rabbits to develop antibodies to HIV, which was considered a major breakthrough. Han said he initially accidentally mixed human blood with rabbit blood making the potential vaccine appear to increase an immune defense against HIV, the virus that can cause AIDS. Han continued to spike the results to avoid disappointing Cho, his mentor, after the scientific community became excited that the team could be on the verge of a vaccine.
He’s now been sentenced to 4 1/2 years in prison for faking research reports, and to repay the NIH $7.2 million in misused grant money. This was an extensive program of faked results (see this post at Retraction Watch from 2013, when the Office of Research Integrity made its report on the case). This went on for years, with the results – presented at multiple conferences in the field – being the basis for an entire large research program.
How someone ends up in this position, that’s what you wonder. But it’s a classic mistake. Fred Schwed, in Where Are the Customer’s Yachts?, laid out the equivalent situation in investing. I don’t have the exact quote to hand, but it was something like “They got on the train at Grand Central Station – they were just going uptown to visit Grandma. But the next thing they knew, they were making 80 miles an hour, at midnight, through Terre Haute, Indiana”. In a more somber key, Macbeth experiences the same feeling in Act 3, scene 4: “I am in blood. Stepped in so far that, should I wade no more, returning were as tedious as go o’er.” It’s such an old trap that you’d think that people would be looking out for it more alertly, but I supposed that the people who fall into it never think that it’ll happen to them. . .