I wanted to mention an upcoming meeting, for people in the Boston/Cambridge area, on DNA-encoded library technologies – Friday, November 6, at AstraZeneca’s site in Waltham. I’ll be helping moderate a panel discussion at the end of the meeting, but there are speakers during the day from Harvard (David Liu) as well as AstraZeneca, GSK, Roche, Ensemble, Vipergen, NuEvolution, X-Chem and the ETH – pretty much all the big players in this area. I’ve long been interested in the possibilities of screening Carl Sagan-esque billions-and-billions of compounds, and I look forward to seeing what the state of the art is like.
There have been several blog posts here about this field, but for background, the Wikipedia article is quite thorough. (Wikipedia, as an aside, is in my opinion one of the great modern works of the human race). Here’s an open-access Accounts of Chemical Research article on the field, from Dario Neri (who’ll be speaking at the conference), and here’s a recent look at macrocycle libraries prepared in this way (from Ensemble, and Stephen Hale, a co-author on this paper, will be speaking as well). And this recent issue of Current Opinion in Chemical Biology is a themed one around various sorts of encoded libraries, with several interesting papers.