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Pfizer Cuts in the UK

Pfizer’s Neusentis research unit near Cambridge (UK) has been shut down. That’s what I’m hearing from more than one source, although there appears (so far) to be little or no public announcement about this. To the best of my knowledge their big focus there was pain, which has been a rough therapeutic area to make a living in. It’s interesting that this is taking place while the Pfizer-Allergan deal is still in media res, but this must have been planned for a while. . .

 

Update: story from the Financial Times.

16 comments on “Pfizer Cuts in the UK”

  1. mama-san says:

    This follows the redux of Icagen as a CRO and termination of Neusentis chemistry in NC. New therapeutics for neuropathic pain, even when there’s supposedly validating human genetic data (Nav1.7), remains elusive.
    http://www.fiercebiotech.com/story/four-years-after-buyout-pfizer-spins-icagen-ion-channel-platform-back-out/2015-07-02

    1. Colonel Sanders says:

      Good thing I was reading the Louisville Courier-Journal today. Apparently congenital insensitivity to pain, associated with Nav1.7 KO (in vivo), is also accompanied by elevated levels of Penk mRNA which means elevated endogenous opioids (enkephalins). So it sounds like you get a two for one deal – reduced potentiation of nociception (Nav1.7 KO), plus elevated opioids. Kind of like my secret recipe of 11 herbs and spices. So if Wood et al are correct (this time round), Neusentis may need to add a measure of opioid agonists, in combination with a selective Nav1.7 inhibitor, to achieve an efficacious pain killer – they probably already tried that. Hopefully there’s synergy to enable lower dosing of either opioid or Nav1.7 inh. Then again, may I also recommend a combo meal of KFC and taters.

      http://www.nature.com/ncomms/2015/151204/ncomms9967/full/ncomms9967.html

  2. Anon says:

    Must be due to that shortage of potential new hires in STEM we keep hearing about.

  3. Me says:

    Nah, it’s because Pfizer are $%#@!

  4. dearieme says:

    “The name, location, and philosophy of Neusentis epitomises the future of drug discovery and development at Pfizer.” They said it.

    1. Rule (of 5) Breaker says:

      Foreshadowing at its finest!

  5. patrick says:

    Perhaps it is because Allergan is working towards neurotoxin-mediated blockade of neuropathic pain?

  6. Anon says:

    This is a very good move by Pfizer for all involved:

    1. The brilliant scientists who work at Neusentis can be recycled to create exciting new biotechs that understand how to create value with innovation, without the stifling idiocy of Pfizer management.
    2. The cash that Pfizer is milking by liquidating this investment can be recycled back to its investors, so that they can invest directly into the biotechs mentioned in 1 above without wasting their money through Pfizer.
    3. Pfizer management will soon be fired as the company continues to whither away into obsolescence, so they will never have the chance to destroy value in this manner again as nobody will want to hire them, work for them, or with them, or otherwise invest in them.

  7. Nick K says:

    Neusentis didn’t last long, did it?

  8. Lucifer says:

    Neusentis apparently have a postdoc program – what an education as to future prospects as a scientist in the pharma industry in the UK – after a minimum of eight years hard study, laid off before you even start your first “real” position.

    http://www.neusentis.com/CurrentPostdocs.php

  9. Berzelius says:

    GSK also announced merge with vaccine division of Novartis, 170 jobs are uncertain on the Wavre site (Belgium)

  10. Dreamweavers says:

    “Every time you are tempted to react in the same old way, ask if you want to be a prisoner of the past or a pioneer of the future. If you focus on success, you’ll have stress. But if you pursue excellence, success will be guaranteed. ”

    https://www.youtube.com/watch?v=89L5p7mcxuw&linkId=19252833

    https://www.youtube.com/watch?v=r2krxkXouQM

  11. petros says:

    Sad news. Best wishes to those I know and their colleagues.

    Granta Park has suffered a few biotech site closures now,

  12. dearieme says:

    “if you pursue excellence, success will be guaranteed” Dear God, simply a lie.

  13. smurf says:

    From now on the ex Neusentis guys are gonna have to be a bit more entrepreneurial I guess. Like their former leader, who was hired by the UK government as head of a Quango that is supposed to drive the UK’s technology and innovation strategy. Couldn’t make up all this shit.

  14. Anonymous Researcher snaw says:

    Pfirst Pfallergan Pfirings; probably not the last!

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