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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    Boost Your NAD And Fix It All?

    Here’s a paper from a few weeks back that I missed during the holidays: work from the Sinclair labs at Harvard showing a new connection between SIRT1 and aging, this time through a mechanism that no one had appreciated. I’ll appreciate, in turn, that that opening sentence is likely to divide its readers into those… Read More
  • Aging and Lifespan

    Google Versus Aging

    If you haven’t heard that Google is now funding research into human aging and lifespan, they’ll be very disappointed. There’s been plenty of publicity, which I find sort of interesting, considering that there’s not too much to announce: The Time article—and a Google blog post released at the same time—provided scant deta… Read More
  • Aging and Lifespan

    A New Pathway For Memory

    As someone who will not be seeing the age of 50 again, I find a good deal of hope in a study out this week from Eric Kandel and co-workers at Columbia. In Science Translational Medicine, they report results from a gene expression study in human brain samples. Looking at the dentate gyrus region of… Read More
  • Aging and Lifespan

    How Rapamycin Extends Lifespan: Not By Slowing Down Aging

    A few years ago, there came the interesting news that rapamycin looked as if it prolonged lifespan in mice. That result is robust; it’s been replicated. Now a large multicenter effort in Germany has looked closely at this effect, and they have many more details about what’s going on. The big question is: does rapamycin… Read More
  • Aging and Lifespan

    Resveratrol: What’s It Do For Mitochondria?

    I’ve been meaning to blog about this new paper in PLOS Biology on resveratrol’s effects on mitochondria. It’s suggesting that the results previously reported in this area cannot be reproduced, namely the idea that resveratrol increases mitochondrial biogenesis and running endurance. In fact, says this new paper, the whole mechanis… Read More
  • Aging and Lifespan

    A New Book on Longevity Research

    The University of Chicago Press has sent along a copy of a new book by DePaul professor Ted Anton, The Longevity Seekers. It’s a history of the last thirty years or so of advances in understanding the biochemical pathways of aging. As you’d imagine, much of it focuses on sirtuins, but many other discoveries get… Read More
  • Aging and Lifespan

    New Sirtuin Inhibitors

    And since that last post was about sirtuins, here’s a new paper in press at J. Med. Chem. from the Sirtris folks (or the Sirtris folks that were, depending on who’s making the move down to PA). They report a number of potent new sirtuin inhibitor compounds, which certainly do look drug-like, and there are… Read More
  • Aging and Lifespan

    Resveratrol Gets Some Details Cleared Up

    I’ve been meaning to write on this paper, from David Sinclair and co-workers, on the mechanism of resveratrol action. The backstory is so long and convoluted that you’re going to have to set aside some time to catch up if you’re just joining it (paging back through this category archive will give you some play-by-play). Read More
  • Aging and Lifespan

    Caloric Restriction Flops?

    Nature is out today with a paper on the results of a calorie-restriction study that began in 1987. This one took place with rhesus monkeys at the National Institute of Aging, and I’ll skip right to the big result: no increase in life span. That’s in contrast to a study from 2009 (also in rhesus) Read More
  • Aging and Lifespan

    Update on the Buckyball Longevity Paper

    You’ll remember the life-extending fullerenes paper that I blogged about here, and the various problems with it that sharp-eyed readers here spotted. (These drew comments from the lead author here and here). Now the journal has issued a correction that covers some of these issues, along with the following Editor’s Note: It should be not… Read More