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Posts tagged with "Aging and Lifespan"

  • Aging and Lifespan

    Resveratrol in Humans: Results of a Controlled Trial

    The effects of resveratrol have been controversial, to say the least. Arguments rage about whether (and how) it affects the various sirtuin pathways, what those various sirtuin pathways are and what they do, and what the compound does in animal models at all (whether you care about the mechanism or not). That last topic recently… Read More
  • Aging and Lifespan

    The Latest Sirtuin Controversy

    As promised, today we have a look at a possible bombshell in longevity research and sirtuins. Again. This field is going to make a pretty interesting book at some point, but it’s one that I’d wait a while to start writing, because the dust is hanging around pretty thickly. Some background: in 1999, Sir2 the… Read More
  • Aging and Lifespan

    Big Sirtuin News

    This will be the subject of a longer post tomorrow, but I wanted to alert people to some breaking news in the sirtuin/longevity saga. It now appears that the original 2001 report of longevity effects of Sir2 in the C. elegans model, which was the starting gun of the whole story, is largely incorrect. That… Read More
  • Aging and Lifespan

    SRT1720: Good (And Confusing) News for Obese Mice

    Readers of this blog will be fairly familiar with the long, interesting story of sirtuin activators. Today we will speak of SRT1720, of which we have spoken before. This molecule was described in 2007 as an activator of Sirt1 with beneficial effects in rodent models of diabetes. But both of those statements were called into… Read More
  • Aging and Lifespan

    mINDY Mice – No Obesity, No Diabetes?

    Caloric restriction increases healthy lifespan. That’s true in a range of organisms, and probably in humans. But it’s never going to be popular – and what’s more, it’s not going to be feasible, either, given how clearly people like to eat. So the search has been on for just how it exerts its effects, with… Read More
  • Aging and Lifespan

    Live Long and Prosper (and Be Bright Yellow at the Same Time)

    I’ll freely admit to being very interested in research on aging and lifespan. It’s a great subject from a scientific (and philosophical) point of view, but perhaps the prospect of turning 50 years old next year has something to do with it, too (not that that age seems anywhere near believable from my end). Model… Read More
  • Aging and Lifespan

    Resveratrol (SRT501): Development Halted

    Back in May, GlaxoSmithKline halted a trial of SRT501, which is a formulation of resveratrol, in myeloma. Now the folks at the Myeloma Beacon site are the first with the news that the company has halted all further development: According to a GlaxoSmithKline spokesperson, an internal analysis of the kidney failure cases has concluded that… Read More
  • Aging and Lifespan

    Dapsone Prolongs Life? Well, In Nematodes It Does. . .

    Get ready for the life-extension folks to jump on this one: there’s a report out in PNAS that the longtime treatment for leprosy (Hansen’s disease), diaminodiphenylsulfone (DDS or dapsone), also prolongs life in the nematode C. elegans. We seem to be talking about nematodes a lot around here recently. The authors of the current study… Read More
  • Aging and Lifespan

    Does Resveratrol Really Work? And Does SRT1720?

    You’ll recall that we recently had the flap over two GSK/Sirtris executives running their own sideline business selling resveratrol as a dietary supplement. There’s a lot of it out there, understandably, since the publicity around the compound has been intense for several years now. But even if it works, how likely is it that a… Read More
  • Aging and Lifespan

    GSK’s Response to the Sirtuin Critics

    OK, time (finally) for the latest chapter in the GSK-Sirtris saga. (This is going to get fairly geeky, so feel free to skip ahead if you’re not into enzymology). You’ll recall from previous installments that Amgen and Pfizer, among others, had disputed whether the reported sirtuin compounds worked the way that had originally been report… Read More