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Posts tagged with "Analytical Chemistry"

  • Analytical Chemistry

    Electron Diffraction Comes Through Again

    Here’s more evidence of the power of the MicroED electron diffraction technique: this new paper reports the structure of two reactive organometallic species whose structures could not be determined by either NMR methods or conventional X-ray crystallography. One of them is the zirconium hydride species known as Schwartz’s reagent (zirco… Read More
  • Analytical Chemistry

    NMR Protein Structures vs. X-Ray ones

    Here’s a neat paper that’s shown up on arXiv.org on protein structures. The authors, from Yale and Edinburgh, are specifically comparing X-ray crystallographic structures with NMR-determined ones in solution. It’s widely known that when you look at the same (or nearly the same) proteins by both those methods that you see small but… Read More
  • Analytical Chemistry

    We Have the Touch

    OK, let’s get reductionist, and let’s see why getting reductionist often works so well. How do you know when your finger has touched something? You feel it – but how do you feel it? Your nerves have sent an impulse to your brain, which interprets it as something having physically come into contact with your… Read More
  • Analytical Chemistry

    A New Form of Carbon

    Here’s today’s weird molecule, for sure. A collaboration between IBM-Zürich and Oxford has reported a new allotrope of carbon, this one an 18-membered ring of alternating triple and single bonds (!) People have been speculating about such structures for years, but they appear to be too reactive to spot easily in the wild. There’s… Read More
  • Analytical Chemistry

    The Enantiomers Did What, Now?

    In today’s episode of “Fun With Chirality”, we have a look at phenomenon that could be very useful, come out of the blue, and which the very authors who report it have no explanation for. This is from a new paper in Angewandte Chemie from a team in Germany (TU-München) who have been looking at… Read More
  • Analytical Chemistry

    Acronym Fever. We Need an Acronym For That.

    The Wall Street Journal published a provocative article the other day, entitled “Don’t Understand Moronic Bromides?” about the proliferation over the years of acronyms in science.(Note the old-fashioned usage of “bromide” derived from the early sleeping pills). And while it’s a cranky piece, it’s not wrong. Read More
  • Analytical Chemistry

    Crystals and Their Weirdness

    Let’s talk crystals for a few minutes. Those of us (like me) who are familiar with chemistry and biology, but who are not crystallographers themselves, will know the broad outlines of X-ray crystallography, and can appreciate its extension to diffracting electrons instead of X-rays. But there are a lot of odd and subtle things that… Read More
  • Analytical Chemistry

    A Completely New Way to Picture DNA in Cells

    Just how are things organized in a living cell? What’s next to what, in three dimensions? That is, of course, a really hard question to answer, but we’re going to have to be able to answer it in a lot of contexts (and at high resolution) if we’re ever going to understand what’s going on… Read More
  • Analytical Chemistry

    Natural Product Artifacts

    Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More
  • Analytical Chemistry

    Absolute Configuration With Electrons

    When I first wrote about small-molecule structures obtained by microED (electron diffraction), I wondered if there were some way to get absolute stereochemistry out of the data (as you can with X-ray diffraction under the right conditions). Several groups have been working on just that problem, and this new paper now shows that it can… Read More
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