Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.
Here’s today’s weird molecule, for sure. A collaboration between IBM-Zürich and Oxford has reported a new allotrope of carbon, this one an 18-membered ring of alternating triple and single bonds (!) People have been speculating about such structures for years, but they appear to be too reactive to spot easily in the wild. There’s… Read More
In today’s episode of “Fun With Chirality”, we have a look at phenomenon that could be very useful, come out of the blue, and which the very authors who report it have no explanation for. This is from a new paper in Angewandte Chemie from a team in Germany (TU-München) who have been looking at… Read More
The Wall Street Journal published a provocative article the other day, entitled “Don’t Understand Moronic Bromides?” about the proliferation over the years of acronyms in science.(Note the old-fashioned usage of “bromide” derived from the early sleeping pills). And while it’s a cranky piece, it’s not wrong. Read More
Let’s talk crystals for a few minutes. Those of us (like me) who are familiar with chemistry and biology, but who are not crystallographers themselves, will know the broad outlines of X-ray crystallography, and can appreciate its extension to diffracting electrons instead of X-rays. But there are a lot of odd and subtle things that… Read More
Just how are things organized in a living cell? What’s next to what, in three dimensions? That is, of course, a really hard question to answer, but we’re going to have to be able to answer it in a lot of contexts (and at high resolution) if we’re ever going to understand what’s going on… Read More
Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More
When I first wrote about small-molecule structures obtained by microED (electron diffraction), I wondered if there were some way to get absolute stereochemistry out of the data (as you can with X-ray diffraction under the right conditions). Several groups have been working on just that problem, and this new paper now shows that it can… Read More
The number of stories and journal articles about how CRISPR DNA-editing technology works, has worked, and is planned to work are beyond counting. How about an article about how to stop it in its tracks? That’s this one, just published in Cell from a multicenter team in Cambridge and New York. It describes a screening… Read More
I had the chance yesterday to attend a one-day symposium on Cryo-EM (and MicroED) techniques here in Cambridge. The whole thing was co-hosted by ThermoFisher, whom I gather are having a glorious time selling these instruments and want to extoll their virtues as much as possible, and by MIT. It helps that there are a… Read More
This is a good brief overview of a topic that’s becoming more important all the time: analysis on the single-cell level. And as the authors mention, it’s partly a case of wanting to do this, and partly a case of there being no other choice. Larger pooled tissue samples just don’t have the level of… Read More
