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Posts tagged with "Animal Testing"

  • Animal Testing

    Enough With the Mouse Behavioral Models?

    This piece in STAT is well worth a read. The author, Adam Rosenberg of Rodin Therapeutics, is ready to ditch rodent-centric models for human CNS disease, and I can see where he’s coming from. I’ve often said that when I think back on my Alzheimer’s and schizophrenia drug discovery days (back when I was first… Read More
  • Animal Testing

    An Expensive Choice for Duke

    You may have seen the headlines about a large settlement ($112.5 million) that Duke University is paying the government. This goes back to Erin Potts-Kant, a clinical research coordinator at Duke Health, as well as (former) professor William Foster and (former) chief of the Pulmonary Division Monica Kraft. The details are many, and some of them… Read More
  • Animal Testing

    A Toxicological Flag

        Here’s a caution from a new paper out of Manchester. The group had been synthesizing inhibitors of PARG (poly-ADP ribose glycohydrolase), an enzyme involved in DNA repair. The general chemotype is shown at right, but there are a number of variations. That fluorine is a new addition, though. The corresponding cyclopropylmethyl se… Read More
  • Animal Testing

    Melanocortin: It’s Not Just For Lizards Any More

    If you’re looking for a good example of evolution-as-a-tinkerer, the melanocortin receptors would be a good place to start. From a single starting point, they’ve ended up as a family of related proteins that do completely different things. And the hormones that bind to them have radiated out as well: they’re all derived by process… Read More
  • Alzheimer's Disease

    Just How Worthless Are the Standard Alzheimer’s Models?

    As mentioned yesterday, Alzheimer’s therapies have, for the most part, been a cliff over which people push bales of money. There are plenty of good reasons for this: we don’t really know what the cause of Alzheimer’s is, when you get down to it, and we’re the only animal that we know of that gets… Read More
  • Animal Testing

    Trouble at Santa Cruz Biotechnology

    The commercial antibody market is already a mess, although that’s not a new development, but it’s gotten messier. Santa Cruz Biotech, one of the big suppliers, is getting out of a big part of the business. Actually, “being forced out of the business through their own actions” is probably a better description. The company has… Read More
  • Animal Testing

    A New Chemotherapy Idea

    This is a study whose immediate applications are in the clinic, but it could have follow-on effects in drug discovery and development as well. Writing in Science Translational Medicine, a team from the Moffitt Cancer Center and USF (with analytical help from Bruker) have been trying a new approach in mouse models of cancer. The… Read More
  • Animal Testing

    A Terrific Paper on the Problems in Drug Discovery

    Here’s a really interesting paper from consultants Jack Scannell and Jim Bosley in PLoS ONE, on the productivity crisis in drug discovery. Several things distinguish it: for one, it’s not just another “whither the drug industry” think piece, of which we have plenty already. This one get quantitative, attempting to figure out… Read More
  • Animal Testing

    Mutated Mutations (And Other Rodent Study Problems)

    Here’s one for the “Dang it, now I have to think about that, too” file. A recent paper suggests that there are mutations in many genetically modified mouse models that could well be confounding their phenotypes. The problem is that so many of these are done from very similar embryonic stem cells and in very… Read More
  • Animal Testing

    Is Everything Getting Fatter?

    Here’s a weird and interesting paper to think about. There’s an unfortunately clear trend in human populations towards obesity, which seems to have been especially noticeable over the last thirty years or so. (I believe that the average-thinnest US state today would have been the fattest state in 1980, just to give one vivid example).… Read More
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