Skip to Content

Posts tagged with "Biological News"

  • Analytical Chemistry

    Down To the Single Cells

    This is a good brief overview of a topic that’s becoming more important all the time: analysis on the single-cell level. And as the authors mention, it’s partly a case of wanting to do this, and partly a case of there being no other choice. Larger pooled tissue samples just don’t have the level of… Read More
  • Biological News

    Sydney Brenner, 1927-2019

    A scientific giant, Sydney Brenner has died at the age of 92. He was present at the beginning of molecular biology – while in the chemistry department at Oxford, he car-pooled with Dorothy Hodgkin, Leslie Orgel, Jack Dunitz and others over to Cambridge to see Watson and Crick’s new model for the structure of DNA… Read More
  • Biological News

    Targeting microRNAs

    Medicinal chemists spend the vast majority of their time targeting proteins. Enzyme active sites, receptors, allosteric sites, interfacial sites – it’s one protein after another, to the point that you can mentally assume that your compounds are going to be hitting the familiar landscape of backbone amide bonds, pi-interacting tryptophan… Read More
  • Biological News

    Reaching Into the Cell

    One would like to be able to reach into a cell and mess around with its functions in real time. Thanks to CRISPR and other gene-editing technologies, we can (more or less selectively) tweak individual genes, to a wide number of interesting effects. What if that gene just disappears? What if it gets expressed even more?… Read More
  • Analytical Chemistry

    The Good Stuff Goes One Way. . .

    I’ve always like the idea of aptamers – as generally used, that word refers to oligonucleotides that are selected for binding to something else (a protein target, for example). You get to use all the tools of molecular biology, which means that you can start out from insanely huge numbers of possible binders and select… Read More
  • Biological News

    Precision Medicine Real Soon Now

    Here’s a strongly opinionated look at where the “precision medicine” field is these days, and I think that this is just the sort of article that the field (and the journalists covering it) need to see, whether you agree with it or not: In 1999 Francis Collins published a foundational document of precision medicine entitled… Read More
  • Biological News

    Exercise And Its Signaling

    It’s a truism among metabolic researchers that if you could find a drug that simulates the effects of exercise you would be very happy with the market for it. But what causes the effects of exercise? That’s one of those simple questions that members of the general public might think that they know the answer… Read More
  • Biological News

    Quinine’s Target

    Every “history of pharmaceuticals” article ever written probably mentions quinine, and well they should. (I certainly reserved an entry for it while writing my own chemical history book). It’s a classic example of a natural product drug, one that was not known to the classical Mediterranean world but was only appreciated by Europe… Read More
  • Biological News

    Bacteria and Depression: Something to Test

    Microbiome, microbiome – you haven’t been able to turn around in this business the last few years without hitting some sort of story about the microbiome. It’s easy to roll your eyes and decide that it’s all hype, but that’s the thing: it really is important. It can’t be dismissed just because we don’t unde… Read More
  • Biological News

    Room For Improvement

    How much can we improve on Nature? Fixing defective proteins and pathways is one thing, but in those cases we’re trying to get back to what the function should be (and what it is in healthy organisms). But what about “better than healthy”? That’s a tricky area to enter, because (for one thing) billions of… Read More
123...