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Posts tagged with "Business and Markets"

  • Business and Markets

    Another Shot at Major Depression Fails

    This is a big day for clinical trial data, and unfortunately it didn’t get off to a very good start. Everyone is waiting for more data on Biogen’s Alzheimers program later today, but another anticipated trial has already read out. Sage Therapeutics made quite a few headlines in 2017 and 2018 when their trials of… Read More
  • Alzheimer's Disease

    Amgen and Neuroscience

    So Amgen has exited the neuroscience area, with a good-sized round of layoffs at their research site Cambridge. The company has a migraine drug (Aimovig) that they’ll continue to support, and they’ll stick with their existing clinical programs, but it looks like all the early-stage stuff is gone. What does this mean? Not as much… Read More
  • Business and Markets

    The Last of Stemcentrx

    The final implosion of the Stemcentrx deal is worth a note, although I said a lot of what I have to say about it back in December. I want to especially emphasize two points I made back then – first, that the failure of this whole acquisition is different only in degree, and not in… Read More
  • Business and Markets

    Startups And Their Publications

    How much does scientific publication matter? For once, we’re not going to be talking about its role in academia (partly because it obviously means quite a bit there!) No, how much does it matter in industry? Specifically, at highly valued biomedical startups? That’s the subject of this new paper by John Ioannides and co-authors, and… Read More
  • Biological News

    Virus-Only Gene Editing, Or Not?

    I wrote here about a new company (Homology Medicine) that claimed to have a viral method for gene editing that did not involve any sort of double-strand DNA breaking enzyme (as you need during the CRISPR, TALENs, or zinc-finger nuclease methods). That’s a pretty interesting claim, because double-strand breaks (DSBs) are powerful but can be… Read More
  • Business and Markets

    Revenues From New Drugs – And Thoughts on Chance

    Here’s an interesting analysis of the industry from IDEA Pharma, via Endpoints. They’re looking at the revenues from the more recent drugs in the pipeline (approved in the last five years) and comparing that to each company’s total R&D spending. The list is all Big Pharma – the cutoff is companies that have at least… Read More
  • Business and Markets

    AbbVie, Allergan, Ugh

    News broke yesterday morning (first at the Wall Street Journal, I believe) that Abbvie has agreed to acquire Allergan. This is one of the larger pharma mergers of recent years, and regular readers of this site will have a pretty good idea of the sigh and roll of the eyes with which I greet it. Read More
  • Academia (vs. Industry)

    Innovation, at Universities and in Industry

    Some thoughts this morning on universities and industry and their contributions to research – and for once, this isn’t going to be another long screed on drug research in particular. No, I’m particularly talking about what each of these brings to R&D in general, and about the places (both conceptual and physical) where they se… Read More
  • Alzheimer's Disease

    A Missed Alzheimer’s Opportunity? Not So Much

    The Washington Post made quite a splash with this story about Pfizer, Enbrel (etanercept), and Alzheimer’s disease. There’s already been a lot of comment about it yesterday on Twitter and in some other venues, but I thought it might be useful to try to sum things up in an easily accessible place. Here we go: Read More
  • Biological News

    Antibody Design, Publicly Challenged

    Comes now some rather disturbing news in the antibody field. These things are extremely important, both as therapeutics and as research reagents, and developing them for either purpose is no stroll down the garden walk. There are a number of techniques for raising and producing antibodies (see that first link), but they all have their… Read More
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