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Posts tagged with "Cancer"

  • Biological News

    Good News in Oncology: More Immune Therapy for Leukemia

    I’ve written a couple of times about the work at the University of Pennsylvania on modified T-cell therapy for leukemia (CLL). Now comes word that a different version of this approach seems to be working at Sloan-Kettering. Recurrent B-cell acute lymphoblastic leukemia (B-ALL) has been targeted there, and it’s generally a more aggressiv… Read More
  • Cancer

    Good News in Oncology: Oncolytic Virus Therapy

    The last few days have brought some good news on some unusual approaches to cancer therapy. First off was Amgen’s report that they’d seen positive results in advanced melanoma using a modified HSV treatment. This is technology that they brought in by buying Biovex in 2011, and as a minor side effect, if it works… Read More
  • Cancer

    ABT-199 Clinical Trial Suspended (Updated)

    Abbott – whoops, pardon me, I mean AbbVie, damn that name – has been developing ABT-199, a selective Bcl-2-targeted oncology compound for CLL. Unlike some earlier shots in this area (ABT-263, navitoclax), it appeared to spare platelet function, and was considered a promising drug candidate in the mid-stage clinical pipeline. Not any mor… Read More
  • Business and Markets

    Time to Refill Your Prescription For Zxygjfb

    The brand names of drugs are famously odd. But they seem to be getting odder. That’s the conclusion of a longtime reader, who sent this along: I was recently perusing through the recent drug approval list and was struck by how strange the trade names have become. Perhaps it is a request from the FDA so… Read More
  • Cancer

    More on Metformin and Cancer (and Alzheimer’s)

    Metformin: what a weird compound it is. Very small, very polar, the sort of thing you’d probably cross off your list of screening hits. But it’s been taken by untold millions of diabetics (and made untold billions of dollars in the process), because it really does reduce glucose levels. It does so though mechanisms that… Read More
  • Biological News

    Reactive Oxygen Species Are Your Friends!

    The line under James Watson’s name reads, of course, “Co-discoverer of DNA’s structure. Nobel Prize”. But it could also read “Provocateur”, since he’s been pretty good at that over the years. He seems to have the right personality for it – both The Double Helix (fancy new edition there) and its notori… Read More
  • Cancer

    Overselling p53 Drugs

    You may have seen some “wonder drug” news stories over the holiday break about compounds targeting p53 – many outlets picked up this New York Times story. The first paragraph probably got them: For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of… Read More
  • Cancer

    Stapled Peptides Take a Torpedo

    I wrote here about “stapled peptides”, which are small modified helical proteins. They’ve had their helices stabilized by good ol’ organic synthesis, with artificial molecular bridging between the loops. There are several ways to do this, but they all seem to be directed towards the same end. That end is something that acts… Read More
  • Cancer

    More on Penn’s T-Cell Therapy

    There’s more news on the T-cell therapy work that I wrote about here and here. The New York Times has an update, and the news continues to be encouraging. So far about a dozen leukemia patients have been treated, and while not everyone has responded, there have been several dramatic remissions. Considering that every candidate… Read More
  • Cancer

    A Good Example of Phenotypic Screening

    I like to highlight phenotypic screening efforts here sometimes, because there’s evidence that they can lead to drugs at a higher-than-usual rate. And who couldn’t use some of that? Here’s a new example from a team at the Broad Institute. They’re looking at the very popular idea of “cancer stem cells” (CSCs), a p… Read More
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