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Posts tagged with "Cardiovascular Disease"

  • Cardiovascular Disease

    The Latest Hydroxychloroquine Data, As of April 11

    We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up. First off is an abstract from the Marseilles IHU group of Dr. Didier Raoult. It presents 1061 patients treated for at least 3 days with their hydroxychloroquine/azithromycin combination, with followup of at least 9 days. It includes the statement… Read More
  • Cardiovascular Disease

    Angiotensin and Coronavirus Infection: The Latest as of April 7

    I wrote here the other day on the recent recommendation that people taking either ACE (angiotensin-converting enzyme) inhibitors or ARBs (angiotensin receptor blockers) should not alter their treatment regimens because of the coronavirus outbreak. Some background on the angiotensin system is here, and here’s an open-access review for those wh… Read More
  • Cardiovascular Disease

    Covid-19, Blood Pressure Medication, and Ibuprofen

    One of the questions that shows up often in the comments to the various Covid-19 posts here (especially this one) and very often in my own emails is whether people who are taking hypertension medications should alter their drug therapy based on the coronavirus epidemic. Most of those questions are specifically about ACE inhibitors (all… Read More
  • Cardiovascular Disease

    Angiotensin and the Coronavirus

    There’s quite a bit of confusion around the ACE proteins and coronavirus infection, and I can see why. The names in this area are pretty confusing, for one thing, and if you’re not familiar with the tangled feedback loops that you get in human biology, it all starts to look like a tangle of wires… Read More
  • Aging and Lifespan

    Metformin and Exercise

    I’ve written about metformin quite a few times over the years on the blog, and for several reasons. It is (for starters) obviously a frontline drug for treatment of Type 2 diabetes, a condition that has unfortunately become more and more common in the world as the world puts on more and more weight. (Side… Read More
  • Cancer

    A Run of Contrary Results

    From the outside, medical progress looks a lot easier than it really is. Well, I realize that’s true of a lot of things, but it’s especially true in progress against disease, and that’s especially especially true (as I’ve said here before) when you’re talking about dietary influences and what can be learned from them.… Read More
  • Cardiovascular Disease

    Inhaled Nanoparticles – Good Ones, That Is

    Never give up on drug delivery ideas – that’s one of the big points I get out of this paper. The authors, part of a multi-center team from sites in Italy and Germany, have previously shown that calcium phosphate nanoparticles could be a good carrier for delicate cargo such as microRNAs. Such things tend to… Read More
  • Cardiovascular Disease

    AMPK: Time To Think Hard

    AMP-activated protein kinase, now that’s an enzyme for you. It sits at the center of a cell’s metabolic switchboard, and if you’re talking about anything to do with the response to levels of fuel like glucose or fatty acids and determination of their downstream fates, then AMPK is almost certainly crucial. Activating the enzyme se… Read More
  • Cardiovascular Disease

    Hold On, Merck’s CETP Inhibitor Actually Works?

    Well, maybe. I have to admit that my first reaction was disbelief. Merck has come out this morning with a statement that its long-running outcomes trial with anacetrapib, their cholesteryl ester transfer protein (CETP) inhibitor, had positive results. Specifically, they say that the trial. . . . . .met its primary endpoint, significantly reducing m… Read More
  • Cardiovascular Disease

    Two Diabetes Drug Mysteries

    Here are some data to file under “Drugs do things that we don’t expect”. The SGLT-2 inhibitors are a class of diabetes medications that work by inhibiting the sodium/glucose transporter 2 protein in the kidneys. That keeps glucose from being reabsorbed there; instead, more of it is removed in the urine, and that lowers circulating… Read More