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Posts tagged with "Chemical Biology"

  • Analytical Chemistry

    Clicked DNA: From Lab Curiosity to Analytical Technique

    I’ve written a few times about an odd sort of unnatural DNA sequence, where some of the nucleotides are connected via “click” triazole units rather than the traditional polyphosphate backbone. I remember wondering what the chemical biology community would make out of these things, and I wanted to report on at least one ingenious a… Read More
  • Chemical Biology

    4-Azidophenylalanine: A Warning

    There’s a reagent used in chemical biology and protein labeling that should be getting a bit more attention than it does. Not because it’s useful – that’s already known – but because it can explode. Here’s the paper (from UC-Irvine and Amgen), and the compound is the 4-azido derivative of phenylalanine. Interest… Read More
  • Chemical Biology

    21st Century Enzymes

    Here’s a remarkable paper that shows how enzymes can be engineered to turn out some very unnatural-looking structures. Frances Arnold’s group at CalTech has published on a great deal of work in this area in the past, and this latest variation is something to see. They’ve been working with various heme proteins, since that reactive… Read More
  • Chemical Biology

    New Chemistry, And Its Limits

    Here’s an article in Nature Chemistry on organic synthesis and drug discovery, from a distinguished group of drug-industry chemists. The authors are going over a number of areas where medicinal chemistry could make use of more advanced synthetic techniques, and they’re good ones. For example, “From an industry perspective, the mos… Read More
  • Biological News

    Alarmingly Functional Disorder

    Let’s think for a bit about how proteins bind to each other. After all, messing around with that is what keeps everyone in the drug industry employed, and the unmessed varieties of such binding events are what keep us all vertical and above room temperature, so it’s a worthy subject. The mental picture is of… Read More
  • Chemical Biology

    More Proteins Than You Ever Thought

    When you take an NSAID (naproxen, ibuprofen, aspirin, etc.), how does it work? This is one of those questions that improves on further inspection – or deteriorates, according to your point of view, because it just keeps on getting more complicated. For decades, there was no good answer at all, but then there was “It… Read More
  • Chemical Biology

    Digging Through the Proteins, Covalently

    I blogged here last year about some really interesting work from the Cravatt group at Scripps. It’s sort of an intersection between fragment-based screening and screening in cells, which is an intersection that I’d previously never thought existed. That’s because fragment screening typically involves biophysical methods (NMR, SPR… Read More
  • Biological News

    A Close Look at Protein Head Counts

    So how many proteins are there in a living cell? Not how many different proteins, although that’s a pretty good question all by itself, one that’s been investigated pretty thoroughly. But how many actual protein molecules are there of each of those? This new paper is the latest attempt to answer that one, from the… Read More
  • Biological News

    The Landscape of Kinase Inhibitors

    I’ve been meaning to link to this article, which is the best overview I know of for kinase inhibitors. The authors (a large multicenter team led out of Munich) characterize 243 (!) kinase inhibitors that have made it into human trials across a very wide range of the known kinase enzymes, and the result is… Read More
  • Chemical Biology

    Catching Up With Protein Degradation

    Just a short note today – I know that a lot of readers in the Northeast will be snowed out of work today anyway, but there are plenty of others who aren’t! I wanted to mention this short review on targeted protein degradation in J. Med. Chem. (a subject I last wrote about here). It’s… Read More