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Posts tagged with "Chemical News"

  • Chemical News

    Breaking Bonds With A Gentle Tug

    Organic chemists are used to breaking and forming all sorts of chemical bonds; it’s what we do. But to do that we have to mess around with the energetics, because many (most!) of these processes don’t happen fast enough or selectively enough on their own. (In fact, the fundamental idea of “click” reactions, as introduced… Read More
  • Chemical News

    Buried Treasure – Of a Sort

    A former colleague was telling me the other day about some not-so-pleasant surprises that occurred when he was helping to clean out a lab that hadn’t had some cabinets opened in a while, and I think many readers will have had such experiences. Academic labs are particularly prone to Easter eggs of this sort, since… Read More
  • Analytical Chemistry

    Crystals and Their Weirdness

    Let’s talk crystals for a few minutes. Those of us (like me) who are familiar with chemistry and biology, but who are not crystallographers themselves, will know the broad outlines of X-ray crystallography, and can appreciate its extension to diffracting electrons instead of X-rays. But there are a lot of odd and subtle things that… Read More
  • Chem/Bio Warfare

    An Idiotic Exhibit

    I suppose this will be sort of a chemical engineering, scale-up, process chemistry post. . .and most certainly will be filed here under the “How Not to Do It” category. The Bellingcat group (Dan Kaszeta in particular) have a very interesting look at a display in “Patriot Park” (a military-themed destination located in a town… Read More
  • Cancer

    The Most Synthetically Complex Drug Candidate Ever

    This is quite a synthetic chemistry accomplishment: the halichondrin derivative E7130 has been synthesized on an 11-gram scale by the Kishi group (open-access paper). I’ve copied that structure directly from the published paper, because there’s just not enough time this morning to redraw it! This would surely be the most complex natural… Read More
  • Chemical News

    A New Way For the Machines To Handle Reagents

    I’ve written here about some of the work on high-throughput reaction optimization: setting up dozens (or hundreds, or thousands) of small test reactions to investigate the conditions needed to get particular transformations to go in high yields. There are plenty of useful reactions (especially some widely-used metal-catalyzed ones)  that can… Read More
  • Chemical News

    The Cyclofluidic Story

    The recent post here on automation in chemistry (especially medicinal chemistry) is a good intro for this paper in ACS Med. Chem. Letters. It’s from David Parry, who led Cyclofluidic, and I’ve blogged about them a few times over the years. That was a company formed in 2008 in the UK to try to develop… Read More
  • Analytical Chemistry

    Natural Product Artifacts

    Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More
  • Chemical Biology

    Myristoylation Probes, Rethought

    The need for good chemical probes continues, and (sadly) so does the use of crappy ones. That’s what I took away from this recent paper from a multicenter team out of London. They’re looking at commonly used probes for inhibition of N-myristoyltransferase (NMT) enzymes, and it’s one of those good-news/bad-news situations. N-myrist… Read More
  • Chemical News

    The Downside of Chemistry Automation

    Automation in chemistry (especially industrial chemistry) is so pervasive that we hardly even notice it any more. (I have a whole talk that I give that’s partly on that very subject). But what is automation for? That’s the subject of this short piece in ACS Med. Chem. Letters by Jeffrey Pan of AbbVie. The answer… Read More
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