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Posts tagged with "Chemical News"

  • Chemical Biology

    Myristoylation Probes, Rethought

    The need for good chemical probes continues, and (sadly) so does the use of crappy ones. That’s what I took away from this recent paper from a multicenter team out of London. They’re looking at commonly used probes for inhibition of N-myristoyltransferase (NMT) enzymes, and it’s one of those good-news/bad-news situations. N-myrist… Read More
  • Chemical News

    The Downside of Chemistry Automation

    Automation in chemistry (especially industrial chemistry) is so pervasive that we hardly even notice it any more. (I have a whole talk that I give that’s partly on that very subject). But what is automation for? That’s the subject of this short piece in ACS Med. Chem. Letters by Jeffrey Pan of AbbVie. The answer… Read More
  • Chemical News

    Switching Out of Fossil Fuel Feedstocks

    Industrial chemistry time! Let’s stipulate that the world’s chemical feedstock industries, on the whole, are not what you would describe as environmentally friendly. There are a lot of moving parts, and some of them are definitely better than others (in their use of energy, carbon emissions, and use of renewable resources as starting ma… Read More
  • Chemical News

    Biological Lanthanides, Weirdly

    I hadn’t realized it, but there are some new elements that have been added to the “essential for biochemistry” list, and they’re a bit of a surprise. (I blogged about odd metals in biology a few years ago). I would guess that anything new at this point would be a surprise – the most recent… Read More
  • Chemical News

    Modifying Natural Products

    Here’s a thorough review of a topic that combines complex drug development issues with complex chemistry: trying to optimize the structures of natural products so that they can be more effective drugs. There are detailed looks at examples like the tetracyclines, the polyene macrolides, pactamycin, geldanamycin, and the thiostrepton-like pepti… Read More
  • Chemical News

    Who Cares About Making Ammonia? You Do.

    This paper comes under the heading of “early days, but possibly of great interest”. It demonstrates room-temperature synthesis of ammonia from nitrogen gas using a samarium/molybdenum system, and chemists of all sorts will sit up and that news and say “Hold it. Ammonia is the Haber-Bosch process, isn’t it?” That it is. Read More
  • Chemical News

    Triboluminescence

    I was interested to see this paper, which goes into detail on a chemical phenomenon that many have seen but no one understands very well: triboluminescence. That word meets with a blank stare or instant recognition; there’s not much in between. It means “emission of light when a material is physically broken”, and that encompasses… Read More
  • Analytical Chemistry

    A Close Look at Fragments

    Here’s a look from the D. E. Shaw research team at fragment binding, and even if you don’t do fragment-based drug discovery, it’s worth a read. That’s because the mechanisms by which fragments bind to proteins are most likely the fundamental ones by which larger molecules bind as well; this is the reductionist look at… Read More
  • Chemical News

    Stirring Bar Contamination

    Stir bars – it was the stirring bars all along. That’s the take-home from this paper, which shows definitively that (A) you cannot truly clean one of the things and that (B) the stuff that’s stuck to them can be influencing the next reaction they’re used in. At one level, I think that few organic… Read More
  • Chemical News

    Some Natural Product Weirdness

    Let us take a moment to gaze upon the weirdness of natural products. For an organic chemist, these things can at times be startlingly weird, with structures that keep bringing on the “Well, I never would have thought of that” response. I collect especially odd ones as I see them in the current literature, so… Read More
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