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Posts tagged with "Chemical News"

  • Cancer

    Click Chemotherapy

    So here’s an ambitious idea that’s about to get a hearing in human clinical trials. A startup called Shasqi is using click chemistry as a drug delivery method, and they have a new manuscript on the idea here at ChemRxiv. The idea is this: you produce a modified version of a hyaluronate biopolymer, decorated with… Read More
  • Chemical News

    Are Medicinal Chemists Taking It Too Easy?

    I was speaking to a university audience the other day (over Zoom, of course) and as I often do I mentioned the studies that have looked at what kinds of reactions medicinal chemists actually use. The cliché is that we spend most of our time doing things like metal-catalyzed couplings and amide formation, and well… Read More
  • Chemical News

    The Machines Rise a Bit More

    Here’s a new paper in Nature on computer-generated synthesis of natural products. More formally, you’d call it retrosynthesis, since the thought process in organic chemistry tends to work backwards when you have a particular target that you’re trying to make: “OK, this part could could be made from something like this. . .an… Read More
  • Chemical News

    Rotating Rings of Solvents

    Now here’s a chemistry technique I don’t think I ever would have thought of. This new paper in Nature presents what could be a new way of doing multistep chemistry in a single vessel by the use of solvent layers of different densities in a rapidly rotating container (the examples below are in vessels are… Read More
  • Chemical News

    Generating Crazy Structures

    I feel like a dose of good ol’ organic chemistry this morning, and a (virtual) meeting I attended yesterday gave me a paper to talk about that delivers some. I was speaking with a local group of modelers and computational chemists (BAGIM), and MIT’s Connor Coley was there presenting some of his group’s work. I… Read More
  • Chemical News

    New Drugs and New Structures

    Here’s an interesting paper that’s just appeared in ACS Med. Chem. Letters. The authors (Todd Wills and Alan Lipkus, both working at Chemical Abstracts) have gone back over drug approvals with an eye to the chemical structures involved (and working at CA certainly gives a person a leg up on doing that!) They’re addressing the… Read More
  • Analytical Chemistry

    Phosphine, Life, and Venus

    Well, as a chemist – one who does amateur astronomy on the side, yet – it’s obligatory that I write about the phosphine on Venus paper that came out yesterday. This one’s embargo was spectacularly leaky, so everyone who’s really into this stuff had various kinds of advance warning, but the news certainly has made… Read More
  • Chemical News

    Robo-Chemist: The Latest Version

    So let’s talk robotic chemistry experimentation – that always calms everyone right down, doesn’t it? This new paper in Nature from a group in Liverpool is (at heart) a pretty straightforward implementation of modern reaction optimization, with the added feature that it’s being done by a mobile robot, rolling around the lab… Read More
  • Chemical News

    Chloroquine, Past and Present

    Now that chloroquine is in the news everywhere, I thought it might be interesting to have a closer look at the compound. The first part of this post will be chemistry-heavy, further down we’ll get into the pharmacology and medical uses. Chloroquine’s fame is as an antimalarial drug, and the history of antimalarials starts of… Read More
  • Alzheimer's Disease

    Congo Red

    Many roots of organic chemistry, and of medicinal chemistry in particular, often originate in what might seem like an unlikely place: the dyestuff industry of the late 19th century. I had already known this to some degree, but writing the historical vignettes in The Chemistry Book really brought it home to me. And if you… Read More