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Posts tagged with "Chemical News"

  • Chemical Biology

    Chose Your Controls Wisely

    I’ve been meaning to write about this paper (open access) on some problems with chemical probes, and now’s a good time. There was a well-known article a few years ago about “The Promise and Peril of Chemical Probes”, and this is a deliberate follow-up, starting with its title. Even if you don’t give much of… Read More
  • Biological News

    Med-Chem Should Be Larger Than It Is

    I’m really glad to see this Perspective article in the Journal of Medicinal Chemistry, not least because it hits on a theme that I emphasize whenever I get a chance to speak to graduate student chemistry audiences. The author, Bart Roman, is pointing out that (1) biologics are relentlessly expanding their role in the landscape… Read More
  • Chemical News

    Weird Natural Product Time Again

    So let’s take a break today by looking at some compounds that, to a good approximation, many synthetic organic chemists would agree shouldn’t even exist. Yep, it’s time for a dive into Weirdo Natural Products, as I do every so often around here. I’ll point out some of the more ridiculous features for the non-chemists… Read More
  • Chemical News

    Ripping Out Amines

    I’ve been meaning to write about this new synthetic organic chemistry paper, because it’s just so weird. That adjective probably needs a little explanation. The next few paragraphs will try to provide that; then we’ll get down to the paper itself. Probably a good fraction of the readership here has had at least the sophomore-organ… Read More
  • Analytical Chemistry

    Watery Worlds

    One of the themes of chemistry over the last few decades has been the ability to pay attention to increasingly fine-grained details. We have new instruments that measure smaller and smaller samples and in shorter slices of time, and we’re seeing that the world that we’ve been used to is just an averaged-out look at… Read More
  • Chemical News

    New Electron Tricks in Synthetic Chemistry

    One of specialties of Phil Baran’s group at Scripps the last few years has been electrosynthesis, which has a traditional hmm-interesting-turn-the-page reputation among most synthetic chemists that they’re trying to change. Photochemistry was in roughly the same category at one time, and has become much more mainstream (although it alwa… Read More
  • AI and Machine Learning

    Lab! Of! The! Future!

    This is a good article at C&E News on the “lab of the future”, and I’ll go ahead and make the standard comment that this has been the lab of the future for quite a while now. The idea is to have mechanical automation and experiment-evaluating software fitting together to “close the loop” and make… Read More
  • Analytical Chemistry


    In my experience, most organic and medicinal chemists are always ready to hear about the latest results in two branches of the science: things that explode and things with weird smells. Maybe we are in our way “singularly in touch with the primitive promptings of humanity”, as Captain Grimes says in Decline and Fall (although… Read More
  • Cancer

    Click Chemotherapy

    So here’s an ambitious idea that’s about to get a hearing in human clinical trials. A startup called Shasqi is using click chemistry as a drug delivery method, and they have a new manuscript on the idea here at ChemRxiv. The idea is this: you produce a modified version of a hyaluronate biopolymer, decorated with… Read More
  • Chemical News

    Are Medicinal Chemists Taking It Too Easy?

    I was speaking to a university audience the other day (over Zoom, of course) and as I often do I mentioned the studies that have looked at what kinds of reactions medicinal chemists actually use. The cliché is that we spend most of our time doing things like metal-catalyzed couplings and amide formation, and well… Read More