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Posts tagged with "Chemical News"

  • Chemical News

    Hindered Ethers Made Easier

    Since I mentioned a new Mitsunobu-type reaction yesterday, I should note that a new route to hindered ethers has come out this summer from the Baran group at Scripps. Here’s the ChemRxiv version, and here’s the Nature paper that just appeared. And there are more details at the group’s blog here. It’s an electrochemical react… Read More
  • Chemical News

    Meet the New Mitsunobu

    Well, people have been searching for a reaction like this one for quite a while now: that link describes a catalytic Mitsunobu-like reaction, and the original has always been a transformation that synthetic organic chemists groan about but use anyway. It’s a way of substituting an OH group in one pot with what should be… Read More
  • Chemical News

    Trifluoromethyl Amides, Now Available

    Early-stage medicinal chemists are going to be all over this paper that’s just come out in Nature. That’s because it opens up a whole interesting class of molecules that we’ve never really had access to: N-trifluoromethyl amides. That phrase won’t do much for you unless you’re a synthetic organic chemist, and especiall… Read More
  • Chemical News

    Not All Of Those Compounds Are Real. Again.

    The Nrf2 pathway has been a hot area of research for some years now, particularly in oncology. It’s a basic-leucine-zipper transcription factor that under normal conditions stays mostly out in the cytosol, where it’s under tight regulatory control. Under cellular stress, though, it heads into the nucleus and fulfills its transcription-f… Read More
  • Chemical News

    The One Source of Perfect Crystals

    Unless you’re really into graphene (or other two-dimensional advanced materials) you’ve probably never heard of these guys. Takashi Tanaguchi and Kenji Watanabe at Tsukuba’s National Institute of Materials Science are basically the only source in the world for high-quality crystals of hexagonal boron nitride (hBN), and that is app… Read More
  • Analytical Chemistry

    A New Form of Carbon

    Here’s today’s weird molecule, for sure. A collaboration between IBM-Zürich and Oxford has reported a new allotrope of carbon, this one an 18-membered ring of alternating triple and single bonds (!) People have been speculating about such structures for years, but they appear to be too reactive to spot easily in the wild. There’s… Read More
  • Chemical News

    Can’t Stop the Nitro Groups

    OK, since I’m a medicinal chemist, I have an excellent excuse to avoid the nitro functional group. It’s metabolic trouble, and although there are indeed drugs with nitros on them, they’re exceptions. Some of them, in fact, are antibacterials that rely on that metabolic activation to work, in the same way that there are nitrate… Read More
  • Chemical News

    Sodium Hydride in Aprotic Solvents: Look Out

    Here’s a safety warning for my fellow synthetic organic chemists. It’s a reagent combination whose hazards have been noted before, but a lot of people don’t seem to know about it: sodium hydride in DMSO or other polar aprotic solvents. And yeah, I’ve used that exact combination, too, many times. But I did those reactions… Read More
  • Analytical Chemistry

    The Enantiomers Did What, Now?

    In today’s episode of “Fun With Chirality”, we have a look at phenomenon that could be very useful, come out of the blue, and which the very authors who report it have no explanation for. This is from a new paper in Angewandte Chemie from a team in Germany (TU-München) who have been looking at… Read More
  • Chemical News

    Robotic Flow Synthesis: The Latest Version

    Here’s another step along the way to automated synthesis, in a new paper from MIT. The eventual hope is to unite the software and the hardware in this area, both of which are developing these days, and come up with a system that can produce new compounds with a minimum of human intervention. Let’s stipulate… Read More
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