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Posts tagged with "Chemical News"

  • Chem/Bio Warfare

    An Idiotic Exhibit

    I suppose this will be sort of a chemical engineering, scale-up, process chemistry post. . .and most certainly will be filed here under the “How Not to Do It” category. The Bellingcat group (Dan Kaszeta in particular) have a very interesting look at a display in “Patriot Park” (a military-themed destination located in a town… Read More
  • Cancer

    The Most Synthetically Complex Drug Candidate Ever

    This is quite a synthetic chemistry accomplishment: the halichondrin derivative E7130 has been synthesized on an 11-gram scale by the Kishi group (open-access paper). I’ve copied that structure directly from the published paper, because there’s just not enough time this morning to redraw it! This would surely be the most complex natural… Read More
  • Chemical News

    A New Way For the Machines To Handle Reagents

    I’ve written here about some of the work on high-throughput reaction optimization: setting up dozens (or hundreds, or thousands) of small test reactions to investigate the conditions needed to get particular transformations to go in high yields. There are plenty of useful reactions (especially some widely-used metal-catalyzed ones)  that can… Read More
  • Chemical News

    The Cyclofluidic Story

    The recent post here on automation in chemistry (especially medicinal chemistry) is a good intro for this paper in ACS Med. Chem. Letters. It’s from David Parry, who led Cyclofluidic, and I’ve blogged about them a few times over the years. That was a company formed in 2008 in the UK to try to develop… Read More
  • Analytical Chemistry

    Natural Product Artifacts

    Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More
  • Chemical Biology

    Myristoylation Probes, Rethought

    The need for good chemical probes continues, and (sadly) so does the use of crappy ones. That’s what I took away from this recent paper from a multicenter team out of London. They’re looking at commonly used probes for inhibition of N-myristoyltransferase (NMT) enzymes, and it’s one of those good-news/bad-news situations. N-myrist… Read More
  • Chemical News

    The Downside of Chemistry Automation

    Automation in chemistry (especially industrial chemistry) is so pervasive that we hardly even notice it any more. (I have a whole talk that I give that’s partly on that very subject). But what is automation for? That’s the subject of this short piece in ACS Med. Chem. Letters by Jeffrey Pan of AbbVie. The answer… Read More
  • Chemical News

    Switching Out of Fossil Fuel Feedstocks

    Industrial chemistry time! Let’s stipulate that the world’s chemical feedstock industries, on the whole, are not what you would describe as environmentally friendly. There are a lot of moving parts, and some of them are definitely better than others (in their use of energy, carbon emissions, and use of renewable resources as starting ma… Read More
  • Chemical News

    Biological Lanthanides, Weirdly

    I hadn’t realized it, but there are some new elements that have been added to the “essential for biochemistry” list, and they’re a bit of a surprise. (I blogged about odd metals in biology a few years ago). I would guess that anything new at this point would be a surprise – the most recent… Read More
  • Chemical News

    Modifying Natural Products

    Here’s a thorough review of a topic that combines complex drug development issues with complex chemistry: trying to optimize the structures of natural products so that they can be more effective drugs. There are detailed looks at examples like the tetracyclines, the polyene macrolides, pactamycin, geldanamycin, and the thiostrepton-like pepti… Read More
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