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Posts tagged with "Chemical News"

  • Analytical Chemistry

    The Good Stuff Goes One Way. . .

    I’ve always like the idea of aptamers – as generally used, that word refers to oligonucleotides that are selected for binding to something else (a protein target, for example). You get to use all the tools of molecular biology, which means that you can start out from insanely huge numbers of possible binders and select… Read More
  • Chemical News

    Defending Drug Synthesis

    This article from Science is a good look at the scientific state of organic synthesis in the pharmaceutical industry. It covers a range of topics which will be familiar to regular readers of this blog as well: synthetic advances such as late-stage functionalization, new bond-forming techniques (photoredox chemistry in particular), the intersection… Read More
  • Chemical News

    Blue Light Gives Way to Red

    Photochemistry’s rise over the last ten years or so has been one of the big stories in organic chemistry, but there are still some difficulties with using it. The use of photoredox catalysts has brought blue light into a lot of fume hoods, which is certainly more selective and easier to use than than old… Read More
  • Chemical News

    Leo Paquette, 1934-2019

    So Leo Paquette has died, age 84 – he had been ill for some years (Parkinson’s). Paquette will be well-known to any synthetic organic chemist; his research group at Ohio State had a long record of contributions to the literature. This PDF from the Baran group is an excellent summary of his work, which is… Read More
  • Chemical News

    Automated Route Finding (and Patent Busting)

    Here’s another look at retrosynthesis software, building on the earlier Chematica paper that looked at generating new routes to known compounds. This is a more detailed look at the same idea, using the software to both analyze the existing routes to marketed drugs (and the patent landscape around them) and to come up with new… Read More
  • Chemical News

    Nostalgie de la Boue

    Alfred Bader’s passing reminds me that there’s an earlier generation – now almost completely gone – that regarded the likes of Aldrich Chemical as fancy upstarts. There has (had?) always been a tradition in organic chemistry of making reagents fresh for your own use, either because there were no commercial suppliers (which i… Read More
  • Chemical News

    Alfred Bader, 1924-2018

    You didn’t hear much about Alfred Bader in recent years – he was elderly, retired, and moreover, his company (Aldrich, later Sigma-Aldrich) had in recent years dropped the Aldrich name from its public branding and now operates as MilliporeSigma. But if you’re at all connected with organic chemistry in the second half of the 20th… Read More
  • Biological News

    Right Side, Left Side

    I wrote here about chirality, on several levels, finishing up with some speculations on how we know our left hands from our right and why. As mentioned in that post, that’s one of those questions that can sound stupid and/or trivial until you start to think about it, and as the comments section proved, things… Read More
  • Chemical News

    Ah, Just Pour It Into Salt Water

    Today’s post is one for my fellow organic chemists to wonder over. This new paper from a group at the University of Bari describes a palladium-catalyzed coupling reaction of alkyllithiums and aryl halides. And that in itself is not that remarkable – it’s not easy to get that combination to go, not least because you might… Read More
  • Chemical News

    Machine Learning: Be Careful What You Ask For

    Let the machine learning wars commence! That’s my impression on reading over the situation I’m detailing today, at any rate. This one starts with this paper in Science, a joint effort by the Doyle group at Princeton and Merck, which used ML techniques to try to predict the success of Buchwald-Hartwig coupling reactions. The idea… Read More