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Posts tagged with "Chemical News"

  • Alzheimer's Disease

    Congo Red

    Many roots of organic chemistry, and of medicinal chemistry in particular, often originate in what might seem like an unlikely place: the dyestuff industry of the late 19th century. I had already known this to some degree, but writing the historical vignettes in The Chemistry Book really brought it home to me. And if you… Read More
  • Chemical News

    More VSC Voodoo

    OK, it’s been a few years since I blogged about this particular weirdness, so let’s do some more. There have been a couple more recent reports of the effects of “vibrational strong coupling” on chemical reaction rates. What the heck is that? There’s some background in that link, but we can hand-wave our way through… Read More
  • Chemical News

    The Good Ol’ Grignard

    Once in a while I’ll see someone studying undergraduate organic chemistry, and I’ll mention to them that those reactions that they’re learning – well, a reasonable number of them – actually get used out in the real world. (The students are generally surprised by this news). I think that a prototype of this sort of… Read More
  • Chemical News

    How Deep Is That Literature?

    The literature of synthetic chemistry is large, and it goes back well over a century. Those of us who know the field sometimes despair of the state that literature is in – it can be pretty messy – but we really shouldn’t. It’s actually far more orderly than many other fields, and it has a… Read More
  • Chemical News

    Phosphorylation Without Pain

    Phosphorylation is a prime example of a reaction that’s hugely important in biochemistry that organic synthesis struggles with terribly (as opposed to the efficiency and finesse with which it’s handled in by enzymatic processes). The methods used to attach phosphate esters in the flask are frankly pretty crude (all the way up, or down,… Read More
  • Chemical News

    One Sugar Turns Into Another

    As someone who used a lot of carbohydrates as chiral pool starting materials in grad school, I regard this paper as the next thing to witchcraft. Even folks without carbohydrate experience appreciate readily that there are sugars that you hear about all the time (such as glucose, mannose, and galactose) and some that you hardly… Read More
  • Chemical News

    Pushing Electrons

    A few years back here on this site when I would write about synthetic photochemical methods, the reaction in the comments section was, well, mixed. There would be interest, but there was always a strain of “Bunch of academic publications that will never amount to anything in the real world” as well. The amount of… Read More
  • Chemical News

    Making The Large Rings Catalytically

    Designing useful catalysts is one of the most challenging frontiers in chemistry, and it stretches across the whole field. Inorganic, synthetic organic, analytical, computational – you name it, and there’s a challenge there to pitch in on. The rewards are substantial. Without catalytic reactions, the modern world economy would come to a… Read More
  • Chemical News

    Perverse Polymorphism

    I mentioned polymorphs the other day, and no mention of those should go by without a reference to the classic 1995 article on “disappearing polymorphs” and its 2015 follow-up. This is a controversial area, but what everyone can agree on is that there are numerous cases where some particular crystal form of a compound has… Read More
  • Chemical News

    Another New Form of Carbon – It’s A Weird One

    Here’s a surprise: a report of a completely new (and rather unusual) allotrope of carbon. There doesn’t appear to be a manuscript out there yet, but the results were presented earlier this month at a conference in Richmond and earlier this year at the APS meeting, and caused a stir. Weirdly, this one appears to… Read More