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Posts tagged with "Clinical Trials"

  • Clinical Trials

    Challenge Testing

    OK, it’s time to address the topic of challenge testing against the coronavirus epidemic. Let’s define our terms: by this, I mean “deliberately exposing volunteers to infection by the virus in order to evaluate prophylactic treatments by comparison to controls”. I will say at the outset that I am not in favor of this idea… Read More
  • Clinical Trials

    Pfizer and BioNTech’s First Vaccine Candidate

    We now have a preprint with a great deal of data on the first mRNA coronavirus vaccine candidate from the Pfizer/BioNTech effort. This is actually the first real data set on any of the genetic vaccines, since Moderna’s paper on their Phase I trial has not yet appeared (all we had was a brief press… Read More
  • Clinical Trials

    Africa, African-Americans, and the Coronavirus Vaccines

    I mentioned yesterday in my post about anti-vaccine arguments that there seemed to be suspicions on social media platforms about vaccine testing in Africa. I’ve been looking around for more of that, and finding plenty of it. I’ve also heard from a colleague with some pertinent thoughts about how these things get going, and I… Read More
  • Clinical Trials

    Dexamethasone for Coronavirus Infection

    News came yesterday from the Recovery trial effort in the UK that they had seen positive results from dexamethasone treatment in severely ill COVID-19 patients (news article from Science here). This set off a number of headlines that everyone has since been trying to deal with, unfortunately, so I thought I should try to do… Read More
  • Clinical Trials

    What Might Go Wrong

    With all of my posts here about vaccines and antibodies, it’s only fair that I spend some time talking about the potential toxicology problems with both of those. I remain optimistic about both categories, but it’s for sure that not all the candidates being advanced are going to make it through. So what sorts of… Read More
  • Clinical Trials

    Coronavirus Vaccine Update, June 11

    Since I did a monoclonal antibody update in the last post, here’s one on the vaccine front, where there is a lot of news – and where there are a lot of issues coming up similar to the ones with the antibodies as well. The last vaccine update post was here. What we’re seeing now… Read More
  • Clinical Trials

    Lots of Coronavirus Antibody News

    There’s a lot of interesting antibody news to catch up on, from the early science to clinical trials. A previous post on this subject is here, with links to earlier background explanations, if you would like to catch up on the area. Here, for example, is a report from a large multi-center team in China characterizing… Read More
  • Clinical Trials

    The RECOVERY Trial Reports on Hydroxychloroquine

    The recent implosion of the Surgisphere data papers has been big news. It included one that purported to show no benefit (and actual harm) from hydroxychloroquine treatment, and even more harm when combined with azithromycin – but since the authors have been unable to back up the raw data on this, the paper cannot be… Read More
  • Clinical Trials

    Coronavirus Therapy Update (Remdesivir and Tocilizumab)

    Let’s circle back to remdesivir. We already have the results of the remdesivir Phase II trial that led to its Emergency Use Authorization by the FDA. But now come the first Phase III results, and it’s safe to say that they’re not making anyone happier. The news isn’t bad, but you can’t say it’s particularly… Read More
  • Clinical Trials

    First Results from Moderna’s Coronavirus Vaccine

    This morning brought news from Moderna of the very first human results from trials of their closely-watched mRNA vaccine candidate (mRNA-1273) against the coronavirus. Here’s Stat on the news, and here’s Endpts – the results can be summed up pretty quickly, because it’s all just at the press-release level to start with. The… Read More