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Posts tagged with "Covid-19"

  • Covid-19

    How Well Does the J&J Vaccine Work Against the Delta Variant?

    That’s a question that’s on a lot of people’s minds, because frankly, we have answers that seem to disagree with each other. Let’s have a look: For one, there’s this letter in the NEJM from researchers at Beth Israel Deaconess hospital and from Janssen (J&J’s pharma branch). That’s a look at immunity in… Read More
  • Covid-19

    Too Many Papers

    If you do a search in PubMed for the words “Cov-2 main protease screen inhibitors”, you get 295 hits. That’s as of this morning, of course – there will be more as time goes on. That represents a great deal of work done in a relatively short time (all of the citations, naturally, are from… Read More
  • Covid-19

    More on Vaccine Side Effects

    Back last summer, I was writing blog posts about possible side effects of mass vaccination. For readers who’ve shown up more recently and might have me filed as Defender of Vaccines, that might seem surprising, but remember, I’ve been in drug discovery for a long time now. All drugs, all therapies have side effects. It’s… Read More
  • Clinical Trials

    An Update on Anti-Androgen Therapy for the Coronavirus

    I blogged earlier this year about some interesting androgen antagonist results in coronavirus therapy. The idea is that the TMPRSS serine protease needs to be present at the cell membrane for the entire cell-entry pathway of the virus to work, and that androgen antagonists decrease its expression sharply. As the references in that earlier post… Read More
  • Blog Housekeeping

    An Announcement About the Comment Section

    In many parts of the US, things are returning to normal thanks to the steep drop in coronavirus cases, which in itself is very likely due to a combination of vaccination and warmer outdoor weather. I very much hope that we can continue this process on into the fall under the threat of new variant… Read More
  • Covid-19

    Drug Repurposing for Coronaviruses: Be Careful

    Here’s a new paper (open access) from a large multi-center team of authors urging caution on many of the reports of small-molecule repurposing screens against coronavirus activity. The list of drugs that has shown activity in vitro is long, and the list of potential targets is as well. But when you look at those targets… Read More
  • Clinical Trials

    CureVac Comes Up Short

    I wasn’t planning on having this turn into Coronavirus Vaccine Week again around here, but we do have some news. Yesterday afternoon CureVac, the German mRNA vaccine company, reported results of their Phase III trial in 40,000 patients around the world. They weren’t good. And the data that have come out today don’t make things… Read More
  • Analytical Chemistry

    The Novavax Vaccine Data, and Spike Proteins in General

    1. Novavax Clinical Data Word came yesterday that Novavax had very good safety and efficacy in the trial of their recombinant protein vaccine. This is good news. By this point, the vaccine is much less needed here in the US, but it could be a very important part of getting many other countries vaccinated, due to… Read More
  • Clinical Trials

    Ivermectin As a COVID-19 Therapy

    I last wrote about ivermectin here, but I’m getting so many question about it that I need to revisit the topic. Although (I’ve said this before), I believe that I will regret doing it, because I expect the signal/noise in the comments section to degenerate to mid-pandemic levels in response. The mechanistic story here has… Read More
  • Covid-19

    Machine Learning Deserves Better Than This

    This is an excellent overview at Stat on the current problems with machine learning in healthcare. It’s a very hot topic indeed, and has been for some time. There has especially been a flood of manuscripts during the pandemic, applying ML/AI techniques to all sorts of coronavirus-related issues. Some of these have been pretty far-fetched… Read More