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Posts tagged with "Covid-19"

  • Clinical Trials

    More Vaccine Data, in Advance of More Efficacy

    I know that it’s been a run of vaccine posts around here, but the numbers just keep on coming. Today we have two more papers to look at, both published in The Lancet. – The first is from the SinoVac inactivated virus effort (the CoronaVac vaccine). In this one, the virus is grown in Vero… Read More
  • Covid-19

    Vaccine Possibilities

    Now that we’re seeing that coronavirus vaccines are indeed possible (and are on their way), let’s talk about the remaining unanswered questions and the things that we will be getting more data on. Here are some of the big issues – it’ll be good to see this stuff coming into focus. I’ll put these into… Read More
  • Clinical Trials

    Moderna’s Vaccine Efficacy Readout

    As expected, we have more vaccine news this morning. And the news is good. Moderna reports that their own mRNA candidate is >94% effective (point estimate), with 95 total cases in the trial to date, split 90/5 between the control group and the vaccinated group. 11 of those were severe infections: all 11 in the… Read More
  • Clinical Trials

    Lilly’s Monoclonal EUA

    I’ve been meaning to write about what has to be called a regulatory mystery. Eli Lilly obtained an Emergency Use Authorization for its monoclonal antibody (bamlanivimab) against SARS-Cov-2, but (as detailed in this post) the dosage that they applied for was 700mg. Which is one-quarter of the dose that showed any efficacy against the primary… Read More
  • Covid-19

    Good News on T-Cell Response

    There are several recent preprints and publications that bear on the T-cell immunity story for the coronavirus pandemic, and I wanted to highlight these, since it’s been a big part of the story that’s needed more information for a long time now. Here, for one, is a multi-institute study from the UK. The authors are… Read More
  • Covid-19

    Vaccine Efficacy Data!

    Earlier this morning, Pfizer and BioNTech announced the first controlled efficacy data for a coronavirus vaccine. And the news is good. You may recall that these vaccine trials are set up to get to a defined number of coronavirus cases overall, at which time the various monitoring committees lock the door and unblind the data… Read More
  • Covid-19

    Don’t Make Mine Mink

    Update: importantly, the follow-up news on this story argues that there’s less to worry about than appeared at first. The mutation described below has not actually appeared again in the last two months, and it ability to evade vaccine-raised neutralizing antibodies is still in doubt. There’s a situation in Denmark that deserves some epi… Read More
  • Covid-19

    The Scientific Literature’s Own Pandemic

    One side effect of the coronavirus has been an explosion of lower-quality publications in the scientific literature. This has come in several forms, some more excusable than others. In the former category are the papers that were rushed out earlier this year, observational studies that sometimes investigated possible therapies as well. These were o… Read More
  • Clinical Trials

    The Latest Antibody Data From Lilly and From Regeneron

    We have a new paper in the NEJM from the Eli Lilly effort on monoclonal antibodies against the coronavirus. And there’s no reason not to be up front about it: it’s disappointing. This is the BLAZE-1 trial (mentioned in this recent post), which is studying non-hospitalized patients. It was another trial (ACTIV-3) where this antibody… Read More
  • Covid-19

    More Antibody Data

    Unfortunately, we’re getting a dose these days of “That’s why you run clinical trials”. Word came Monday evening (Peter Loftus in the WSJ, and a Lilly statement) that the ACTIV-3 trial being run by the NIH has shown lack of efficacy for the combination of the Eli Lilly/AbCellera anti-coronavirus antibody (bamlanivimab, LY-Co… Read More