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Posts tagged with "Covid-19"

  • Clinical Trials

    Challenge Testing

    OK, it’s time to address the topic of challenge testing against the coronavirus epidemic. Let’s define our terms: by this, I mean “deliberately exposing volunteers to infection by the virus in order to evaluate prophylactic treatments by comparison to controls”. I will say at the outset that I am not in favor of this idea… Read More
  • Clinical Trials

    Pfizer and BioNTech’s First Vaccine Candidate

    We now have a preprint with a great deal of data on the first mRNA coronavirus vaccine candidate from the Pfizer/BioNTech effort. This is actually the first real data set on any of the genetic vaccines, since Moderna’s paper on their Phase I trial has not yet appeared (all we had was a brief press… Read More
  • Covid-19

    Coronavirus Vaccine Update, July 1

    More vaccine news to catch up on – previous updates and specific topic posts on this subject were on June 15, on June 11, on May 26, on May 18 (with two other posts), on May 14, on May 1, on April 23, and on April 15 (author’s note: yikes). Keep in mind that some of those posts were updated… Read More
  • Chemical Biology

    A Wide Look at Coronavirus Mutants

    Here’s a new preprint that goes a long way to telling us what we need to know about coronavirus antibodies and Spike protein mutations. It’s from Jesse Bloom’s group at the Fred Hutchinson center in Seattle, and it’s another one of those experiments that you could only do with modern molecular biology (and modern bioinformat… Read More
  • Clinical Trials

    Dexamethasone for Coronavirus Infection

    News came yesterday from the Recovery trial effort in the UK that they had seen positive results from dexamethasone treatment in severely ill COVID-19 patients (news article from Science here). This set off a number of headlines that everyone has since been trying to deal with, unfortunately, so I thought I should try to do… Read More
  • Clinical Trials

    What Might Go Wrong

    With all of my posts here about vaccines and antibodies, it’s only fair that I spend some time talking about the potential toxicology problems with both of those. I remain optimistic about both categories, but it’s for sure that not all the candidates being advanced are going to make it through. So what sorts of… Read More
  • Clinical Trials

    Coronavirus Vaccine Update, June 11

    Since I did a monoclonal antibody update in the last post, here’s one on the vaccine front, where there is a lot of news – and where there are a lot of issues coming up similar to the ones with the antibodies as well. The last vaccine update post was here. What we’re seeing now… Read More
  • Clinical Trials

    Lots of Coronavirus Antibody News

    There’s a lot of interesting antibody news to catch up on, from the early science to clinical trials. A previous post on this subject is here, with links to earlier background explanations, if you would like to catch up on the area. Here, for example, is a report from a large multi-center team in China characterizing… Read More
  • Clinical Trials

    The RECOVERY Trial Reports on Hydroxychloroquine

    The recent implosion of the Surgisphere data papers has been big news. It included one that purported to show no benefit (and actual harm) from hydroxychloroquine treatment, and even more harm when combined with azithromycin – but since the authors have been unable to back up the raw data on this, the paper cannot be… Read More
  • Covid-19

    Hydroxychloroquine For Avoiding Infection?

    Most readers will have heard that this paper appeared in the NEJM late yesterday afternoon: it’s something that we haven’t had so far, an actual randomized, double-blinded, placebo-controlled hydroxychloroquine trial. This one was for post-exposure prophylaxis, a mode of treatment made famous by President Trump when he stated several ti… Read More
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