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Posts tagged with "Covid-19"

  • Covid-19

    Monoclonal Antibodies and Vaccines: Q and A

    I’ve had a lot of questions from people about the prospects for monoclonal antibodies and vaccines against the coronavirus, and I thought that it might be helpful to answer them in this format. Let’s start the press conference! We’ll start with monoclonal antibodies. Why are you so optimistic that this technology will work? Two bi… Read More
  • Covid-19

    More Chinese Traditional Medicine, Unfortunately

    I mentioned the other day that what was reported as a hydroxychloroquine trial in China may well have been (or at least begun as) a trial of “traditional Chinese medicine” (TCM). It doesn’t take much digging to turn up a number of registered clinical trials for coronavirus therapy via TCM, actually. Here are a few… Read More
  • Covid-19

    What’s Up With Ivermectin?

    One of the small-molecule drugs that’s getting attention as a possible coronavirus treatment is Ivermectin, which is an interesting story from a couple of different directions. I’ve been getting some inquiries about it, so I thought it was time to have a look. Background on Ivermectin It’s part of a family of natural products call… Read More
  • Covid-19

    Mutations in the Coronavirus Spike Protein

    The last post talked about antibodies to the spike protein of the coronavirus, and one of the main things that everyone has to keep an eye on are the mutations in that area. That has implications for monoclonal antibody therapy, for vaccine production, and for the behavior of the coronavirus itself. Antibodies against the Spike… Read More
  • Covid-19

    Details of a New Anti-Coronovirus Neutralizing Antibody

    There’s a lot of work being done on antibodies for the coronavirus and on the protein domains they recognize. This of course has bearing both on the idea of monoclonal antibody therapies and for the vaccines that are in development, so let’s have a look at the new data. For reference, here’s a background post… Read More
  • Clinical Trials

    Hydroxychloroquine Update, May 4

    It’s been some days since I posted on the hydroxychloroquine situation versus the coronavirus epidemic, but I have been getting plenty of inquiries. So let’s have a look at what’s been going on! Several people have pointed out this new preprint, a retrospective look at 568 patients in Wuhan. Update: there is something odd about… Read More
  • Clinical Trials

    About Remdesivir and About “Game-Changers”

    We’ve had several releases of remdesivir data, and this was not exactly one of those controlled-release formulations. No, this was more in the “chaotic mess” category, with news items coming from several sources with partial information. I decided not to blog on it until the loud banging noises stopped, and I’m glad I did, s… Read More
  • Covid-19

    Monoclonal Antibodies for the Coronavirus (Updated May 5th)

    Antibodies as a therapy Let’s have a look at what is (in my opinion) probably our best shot at a reasonably short-term targeted therapy against the COVID-19 epidemic: the possibility of using monoclonal antibodies. These can be developed more quickly than vaccines, and a lot more quickly than a new targeted small-molecule antiviral. Like ever… Read More
  • Clinical Trials

    Anti IL-6 For Coronavirus Patients: Does It Work, or Not?

    It’s been looking for some time as if these coronavirus infections need a biphasic approach to therapy – an antiviral approach earlier on, and for those in serious trouble, perhaps a shift to immune modulation as the body’s reaction to the virus starts doing even more harm. That post goes into some detail on possible… Read More
  • Covid-19

    The Order of Battle

    Among the many drug-discovery lessons that this pandemic is highlighting is the difficulty of meeting the challenges of a new target, a new pathogen, a new disease, or a new mechanism of action. When you look at the history of the drug industry, the typical time for an effective therapy to be developed from a… Read More